Altered brain reward circuits in eating disorders: chicken or egg?
Altered brain reward circuits in eating disorders: chicken or egg?
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DOI：
10.1007/s11920-013-0396-x
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发表时间：
2013-10
影响因子：
6.7
通讯作者：
Frank, Guido K. W.
中科院分区：
文献类型：
--
作者：
Frank, Guido K. W.
关键词：
神经性厌食症（anorexia nervosa，AN）和神经性贪食症（bulimia nervosa，BN）是严重的精神疾病，死亡率高。我们对进食障碍的神经生物学的了解非常有限，问题仍然是进食障碍中大脑结构或功能的改变是否与状态有关，是疾病的残余还是病前特征。大脑奖励系统是一个相对较好表征的大脑回路，它在进食的驱动力中起着核心作用，与对照组相比，目前或过去患有饮食失调的个体在这些通路中表现出改变。在这里，我们提出，大脑皮层和额叶皮层的结构和功能改变，包括眶额区和扣带回区，这些区域有助于奖励和焦虑处理，可能会导致饮食失调，而这些回路中的适应性变化对营养不良或反复暴饮暴食和净化的反应可能会进一步促进疾病行为，阻碍康复并导致复发。
The eating disorders anorexia nervosa (AN) and bulimia nervosa (BN) are severe psychiatric disorders with high mortality. Our knowledge about the neurobiology of eating disorders is very limited, and the question remains whether alterations in brain structure or function in eating disorders are state related, remnants of the illness or premorbid traits. The brain reward system is a relatively well-characterized brain circuitry that plays a central role in the drive to eat and individuals with current or past eating disorders showed alterations in those pathways compared to controls. Here we propose that structural and functional alterations in the insula and frontal cortex, including orbitofrontal and cingulate regions, areas that contribute to reward and anxiety processing, could predispose to developing an eating disorder and that adaptive changes in those circuits in response to malnutrition or repeated binge eating and purging could further promote illness behavior, hinder recovery and contribute to relapse.
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影响因子：
5.5
作者：
Frank, Guido K. W.;Roblek, Tami;Shott, Megan E.;Jappe, Leah M.;Rollin, Michael D. H.;Hagman, Jennifer O.;Pryor, Tamara
通讯作者：
Pryor, Tamara
影响因子：
17.7
作者：
Crow, Scott J.;Peterson, Carol B.;Mitchell, James E.
通讯作者：
Mitchell, James E.
影响因子：
16.2
作者：
Daw ND;Gershman SJ;Seymour B;Dayan P;Dolan RJ
通讯作者：
Dolan RJ
影响因子：
10.6
作者：
Frank, GK;Bailer, UF;Kaye, WH
通讯作者：
Kaye, WH
影响因子：
3.3
作者：
Carra, K. D.;Chau, L. S.;de Vaca, S. Cabeza;Gustafson, K.;Stouffer, M.;Tukey, D. S.;Restituito, S.;Ziff, E. B.
通讯作者：
Ziff, E. B.