Mucosal adjuvants for vaccines to control upper respiratory infections in the elderly.
Mucosal adjuvants for vaccines to control upper respiratory infections in the elderly.
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DOI：
10.1016/j.exger.2014.01.006
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发表时间：
2014-06
影响因子：
3.9
通讯作者：
Kiyono, Hiroshi
中科院分区：
文献类型：
--
作者：
Fujihashi, Kohtaro;Sato, Shintaro;Kiyono, Hiroshi
流感病毒和肺炎链球菌是导致老年人发病和死亡的两大病原体。由于这两种病原体通过粘膜进入宿主，特别是上呼吸道（URT），因此在粘膜表面引发病原体特异性分泌型伊加（SIgA）抗体（Ab）应答对于老年人的防御是必不可少的。然而，随着年龄的增长，老年人粘膜免疫系统的改变导致无法诱导SIgA抗体来保护免受这些感染。为了克服粘膜免疫衰老，我们已经开发了一种粘膜树突状细胞靶向，新的双佐剂系统，我们证明是一个有吸引力的和有效的免疫调节剂。该系统诱导更平衡的Th 1-和Th 2-型细胞因子应答，其支持粘膜SIgA和系统性IgG 1和IgG 2a Ab应答。因此，该佐剂系统对流感病毒和链球菌的鼻疫苗的适应。pneumoniae感染的小鼠通过支持衰老小鼠模型URT中病原体特异性SIgA Ab应答，成功地提供了保护。总之，双佐剂系统被认为是一个有吸引力的和潜在的重要战略，为老年人粘膜疫苗的未来发展。
Influenza virus and Streptococcus pneumoniae are two major pathogens that lead to significant morbidity and mortality in the elderly. Since both pathogens enter the host via the mucosa, especially the upper respiratory tract (URT), it is essential to elicit pathogen-specific secretory IgA (SIgA) antibody (Ab) responses at mucosal surfaces for defense of the elderly. However, as aging occurs, alterations in the mucosal immune system of older individuals result in a failure to induce SIgA Abs for protection from these infections. To overcome mucosal immunosenescence, we have developed a mucosal dendritic cell targeting, novel double adjuvant system which we show to be an attractive and effective immunological modulator. This system induces a more balanced Th1- and Th2- type cytokine response which supports both mucosal SIgA and systemic IgG1 and IgG2a Ab responses. Thus, adaptation of this adjuvant system to nasal vaccines for influenza virus and S. pneumoniae could successfully provide protection by supporting pathogen-specific SIgA Ab responses in the URT in the mouse model of aging. In summary, a double adjuvant system is considered to be an attractive and potentially important strategy for the future development of mucosal vaccines for the elderly.
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影响因子：
4.4
作者：
Kataoka, K;McGhee, JR;Fujihashi, K
通讯作者：
Fujihashi, K
影响因子：
5.5
作者：
Enioutina, EY;Visic, DM;Daynes, RA
通讯作者：
Daynes, RA
影响因子：
4.3
作者：
Halpern, MD;Kurlander, RJ;Pisetsky, DS
通讯作者：
Pisetsky, DS
DOI：
10.1073/pnas.0903181106
发表时间：
2009-05-12
影响因子：
11.1
作者：
Galli, Grazia;Hancock, Kathy;Stephenson, Iain
通讯作者：
Stephenson, Iain
影响因子：
6.4
作者：
GRAY, BM;CONVERSE, GM;DILLON, HC
通讯作者：
DILLON, HC