Effect of Myocardial Fiber Direction on Epicardial Activation Patterns.
Effect of Myocardial Fiber Direction on Epicardial Activation Patterns.
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DOI：
10.22489/cinc.2020.399
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
MacLeod RS
中科院分区：
文献类型：
--
作者：
Rupp LC;Good WW;Bergquist JA;Zenger B;Gillette K;Plank G;MacLeod RS
纤维结构支配着心脏兴奋的传播，然而，关于纤维取向的生理变异性对心外膜激活的影响知之甚少。为了研究这些影响，我们使用计算机模拟来比较心室激动序列从刺激部位在不同的规则为基础的纤维范围内的心肌内有规律地间隔的深度。我们使用心外膜突破（BKT）的四个特征比较了效果：位置、面积、形状（通过拟合椭圆的轴比计算）和方向。我们的结果显示，随着起搏深度的增加，BKT特征发生变化，例如，无论纤维取向如何，面积增加，形状变得更圆，取向逆时针旋转。此外，单个起搏部位的心外膜激动在位置、面积、轴比和方向上的最大差异分别为1.2 mm、74 mm2、0.16和26°。我们的研究结果表明，纤维方向的变化对BKT的位置，面积和形状的影响可以忽略不计，而波动的BKT方向在响应于纤维领域，特别是心外膜刺激部位。我们的研究结果表明，纤维场的方向在异位搏动的激活模拟中只起次要作用。
Fiber structure governs the spread of excitation in the heart, however, little is known about the effects of physiological variability in the fiber orientation on epicardial activation. To investigate these effects, we used computer simulation to compare ventricular activation sequences initiated from stimulus sites at regularly spaced depths within the myocardium under varying rule-based fiber ranges. We compared the effects using four characteristics of epicardial breakthrough (BKT): location, area, shape (calculated via the axis ratio of a fitted ellipse), and orientation. Our results showed changes in the BKT characteristics as pacing depth increased, e.g., the area increased, the shape became more circular, and the orientation rotated counterclockwise, regardless of the fiber orientation. Furthermore, the maximal differences in epicardial activation from a single pacing site for location, area, axis ratio, and orientation were 1.2 mm, 74 mm2, 0.16, and 26°, respectively. Our results suggest that variability in fiber orientation has a negligible effect on the location, area, and shape of the BKT, while fluctuations were observed in the BKT orientation in response to the fiber fields, especially for epicardial stimulation sites. Our results suggest the fiber field orientation plays only a minor role in activation simulations of ectopic beats.
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作者：
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DOI：
10.1016/j.pbiomolbio.2007.07.012
发表时间：
2008-01
影响因子：
3.8
作者：
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通讯作者：
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