Sensory-motor mechanisms in human parietal cortex underlie arbitrary visual decisions.
Sensory-motor mechanisms in human parietal cortex underlie arbitrary visual decisions.
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DOI:
10.1038/nn.2221
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发表时间:
2008-12
影响因子:
25
通讯作者:
Corbetta, Maurizio
中科院分区:
文献类型:
--
作者:
Tosoni, Annalisa;Galati, Gaspare;Romani, Gian Luca;Corbetta, Maurizio
The neural mechanism underlying simple perceptual decision-making in monkeys has been recently conceptualized as an integrative process in which sensory evidence supporting different response options accumulates gradually over time. For example, intraparietal neurons accumulate over time motion information in favour of a specific oculomotor choice. It is unclear, however, whether this mechanism generalizes to more complex decisions based on arbitrary stimulus- response associations. Here, in a task requiring to arbitrarily associate visual stimuli (faces or places) with different actions (eye or hand-pointing movements), we show that activity of effector-specific regions in human posterior parietal cortex reflects the ‘strength’ of the sensory evidence in favour of the preferred response. These regions, which do not respond to sensory stimuli per se, integrate after learning sensory evidence toward the outcome of an arbitrary decision. We conclude that even arbitrary decisions can be mediated by sensory-motor mechanisms completely triggered by contextual stimulus-response associations.
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