Sensory-motor mechanisms in human parietal cortex underlie arbitrary visual decisions.

Sensory-motor mechanisms in human parietal cortex underlie arbitrary visual decisions.
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DOI:
10.1038/nn.2221
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发表时间:
2008-12
影响因子:
25
通讯作者:
Corbetta, Maurizio
Corbetta, Maurizio
中科院分区:
医学1区
文献类型:
--
作者:
Tosoni, Annalisa;Galati, Gaspare;Romani, Gian Luca;Corbetta, Maurizio

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猴子简单知觉决策的神经机制最近被概念化为一个整合过程,在这个过程中,支持不同反应选项的感官证据随着时间的推移逐渐积累。例如,顶叶内神经元随着时间的推移积累运动信息,有利于特定的眼球选择。然而,目前还不清楚这种机制是否可以推广到基于任意刺激-反应关联的更复杂的决策。在这里,在一个任务中,需要任意关联的视觉刺激(面部或地方)与不同的动作(眼睛或手指向运动),我们表明,在人类后顶叶皮层效应器特定区域的活动反映了“强度”的感官证据,有利于首选的反应。这些区域本身对感官刺激没有反应,在学习感官证据后,它们会整合到一个任意决定的结果中。我们的结论是,即使是任意的决定可以介导的感觉运动机制完全由上下文刺激反应协会触发。
The neural mechanism underlying simple perceptual decision-making in monkeys has been recently conceptualized as an integrative process in which sensory evidence supporting different response options accumulates gradually over time. For example, intraparietal neurons accumulate over time motion information in favour of a specific oculomotor choice. It is unclear, however, whether this mechanism generalizes to more complex decisions based on arbitrary stimulus- response associations. Here, in a task requiring to arbitrarily associate visual stimuli (faces or places) with different actions (eye or hand-pointing movements), we show that activity of effector-specific regions in human posterior parietal cortex reflects the ‘strength’ of the sensory evidence in favour of the preferred response. These regions, which do not respond to sensory stimuli per se, integrate after learning sensory evidence toward the outcome of an arbitrary decision. We conclude that even arbitrary decisions can be mediated by sensory-motor mechanisms completely triggered by contextual stimulus-response associations.
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