Erectile dysfunction in spontaneously hypertensive rats: pathophysiological mechanisms.
Erectile dysfunction in spontaneously hypertensive rats: pathophysiological mechanisms.
复制标题
自发性高血压大鼠的勃起功能障碍：病理生理机制。
DOI：
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
F. Giuliano
中科院分区：
文献类型：
--
作者：
D. Behr;P. Chamiot;J. Bernabé;K. Mevel;L. Alexandre;M. Safar;F. Giuliano
高血压男性勃起功能障碍（艾德）的患病率高于普通人群。艾德在高血压动物中的实验证据很少。本研究通过电刺激海绵体神经（CN）后阴茎海绵体内压的增加和对阴茎体条的等长张力研究，评价了自发性高血压大鼠（SHR）和年龄匹配的血压正常的Wistar-Kyoto大鼠（WKY）在体内的勃起功能。在SHR中，对CN刺激的频率依赖性勃起反应降低。苯肾上腺素诱导较低的身体收缩SHR，虽然pD 2值类似于WKY。血管内皮依赖性舒张ACh受损显着SHR，吲哚美辛改善这些舒张WKY和SHR，后者从而达到类似的值WKY。SHR对硝普钠的躯体舒张作用增强。因此，身体平滑肌的功能障碍性α-肾上腺素能收缩、环加氧酶依赖性收缩肌张力增加和/或内皮依赖性反应性缺陷与SHR勃起机制的改变相关。靶向内皮功能障碍的药物可能延缓高血压并发症艾德的发生。
Hypertensive men have a higher prevalence of erectile dysfunction (ED) than the general population. Experimental evidence of ED in hypertensive animals is scarce. This study evaluates the erectile function of spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto rats (WKY) in vivo by the increase in intracavernosal pressure after electrical stimulation of the cavernous nerve (CN) and by isometric tension studies on corporal strips. Frequency-dependent erectile responses to CN stimulations were reduced in SHR. Phenylephrine induced lower corporal contractions in SHR although pD2 values were similar to WKY. Endothelium-dependent relaxations to ACh were impaired significantly in SHR, and indomethacin improved these relaxations in both WKY and SHR, the latter thus reaching values similar to WKY. Corporal relaxations to sodium nitroprusside were enhanced in SHR. Thus a dysfunctional alpha-adrenergic contraction of the corporal smooth muscle, an increased cyclooxygenase-dependent constrictor tone, and/or a defect in endothelium-dependent reactivity are associated with the altered erectile mechanisms in SHR. Drugs targeting endothelial dysfunction may delay the occurrence of ED as a complication of hypertension.
影响因子：
6.6
作者：
AZADZOI, KM;KIM, N;DETEJADA, IS
通讯作者：
DETEJADA, IS
雄性自发性高血压大鼠选定脑区的性功能和神经肽 Y 水平。
DOI：
10.1152/ajpregu.1991.261.5.r1234
发表时间：
1991
期刊：
The American journal of physiology
影响因子：
--
作者：
Clark,JT;Sahu,A;Mrotek,JJ;Kalra,SP
通讯作者：
Kalra,SP
DOI：
10.1016/0006-291x(90)92168-y
发表时间：
1990-07-31
影响因子：
3.1
作者：
IGNARRO, LJ;BUSH, PA;RAJFER, J
通讯作者：
RAJFER, J