Environmental factors, toxicants and systemic lupus erythematosus.
Environmental factors, toxicants and systemic lupus erythematosus.
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DOI：
10.3390/ijms150916043
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发表时间：
2014-09-11
影响因子：
5.6
通讯作者：
Tay SH
中科院分区：
文献类型：
--
作者：
Mak A;Tay SH
系统性红斑狼疮（SLE）是一种免疫复合物介导的多系统性自身免疫性疾病，主要影响年轻女性。目前认为，SLE和狼疮发作是由遗传易感个体的各种环境因素引发的。各种环境因子和毒物，如香烟烟雾，酒精，职业和非职业相关的化学品，紫外线，感染，性激素和某些药物和疫苗，已被牵连到诱导SLE发病或耀斑在一些病例系列，病例对照和人群为基础的队列研究和极少数随机对照试验。在这里，我们将描述一些这些公认的环境狼疮触发和延续的因素，并解释这些因素如何通过与遗传和表观遗传改变的相互作用，潜在地使免疫系统偏向自身免疫。进一步深入探索潜在的重要环境因素如何与免疫系统和基因组相互作用，触发SLE和狼疮发作，肯定会是预防发病和减缓疾病进展的合理步骤之一。
Systemic lupus erythematosus (SLE) is an immune-complex-mediated multi-systemic autoimmune condition of multifactorial etiology, which mainly affects young women. It is currently believed that the onset of SLE and lupus flares are triggered by various environmental factors in genetically susceptible individuals. Various environmental agents and toxicants, such as cigarette smoke, alcohol, occupationally- and non-occupationally-related chemicals, ultraviolet light, infections, sex hormones and certain medications and vaccines, have been implicated to induce SLE onset or flares in a number case series, case-control and population-based cohort studies and very few randomized controlled trials. Here, we will describe some of these recognized environmental lupus triggering and perpetuating factors and explain how these factors potentially bias the immune system towards autoimmunity through their interactions with genetic and epigenetic alterations. Further in-depth exploration of how potentially important environmental factors mechanistically interact with the immune system and the genome, which trigger the onset of SLE and lupus flares, will certainly be one of the plausible steps to prevent the onset and to decelerate the progress of the disease.
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影响因子：
8.3
作者：
Gardner, Renee M.;Nyland, Jennifer F.;Silva, Ines A.;Ventura, Ana Maria;de Souza, Jose Maria;Silbergeld, Ellen K.
通讯作者：
Silbergeld, Ellen K.
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通讯作者：
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通讯作者：
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作者：
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通讯作者：
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