Mercury exposure, serum antinuclear/antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study.
Mercury exposure, serum antinuclear/antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study.
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DOI：
10.1016/j.envres.2010.02.001
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发表时间：
2010-05
影响因子：
8.3
通讯作者：
Silbergeld, Ellen K.
中科院分区：
文献类型：
--
作者：
Gardner, Renee M.;Nyland, Jennifer F.;Silva, Ines A.;Ventura, Ana Maria;de Souza, Jose Maria;Silbergeld, Ellen K.
汞是一种免疫毒性物质，在啮齿类动物模型中已被证明可诱发自身免疫性疾病，其特征是淋巴细胞增生、免疫球蛋白（IgG和IgE）的过量产生，以及针对位于细胞核抗原的高循环自身抗体（抗核自身抗体，或ANA）或核核自身抗体（抗核核自身抗体，或ANoA）。我们已经报道了接触手工金矿汞的人群中ANA和ANoA水平升高，尽管其他可能调节ANA/ANoA水平的混杂变量没有得到很好的控制。本研究的目的是专门测试与手工采金相关的职业和环境条件（汞暴露除外）是否会影响自身免疫功能障碍标志物的流行。我们测量了血清中ANA、ANoA和细胞因子浓度，并比较了汞暴露的手工采金工人与在相似条件下、具有相似社会经济地位和传染病风险的钻石和祖母绿采金工人的结果。与没有职业汞暴露的钻石和祖母绿矿工相比，汞暴露的金矿工人有更高的可检测到的ANA和ANoA患病率和更高的ANA和ANoA滴度。此外，与钻石和祖母绿矿工相比，血清中检测到ANA或ANoA的汞暴露淘金者血清中促炎细胞因子IL-1β， TNF-α和IFN-γ的浓度显着更高。这项研究提供了进一步的证据，表明汞暴露可能导致受影响人群的自身免疫功能障碍和全身性炎症。
Mercury is an immunotoxic substance that has been shown to induce autoimmune disease in rodent models, characterized by lymphoproliferation, overproduction of immunoglobulin (IgG and IgE), and high circulating levels of autoantibodies directed at antigens located in the nucleus (anti-nuclear autoantibodies, or ANA) or the nucleolus (anti-nucleolar autoantibodies, or ANoA). We have reported elevated levels of ANA and ANoA in human populations exposed to mercury in artisanal gold mining, though other confounding variables that may also modulate ANA/ANoA levels were not well-controlled. The goal of this study is to specifically test whether occupational and environmental conditions (other than mercury exposure) that are associated with artisanal gold mining affect the prevalence of markers of autoimmune dysfunction. We measured ANA, ANoA, and cytokine concentrations in serum and compared results from mercury-exposed artisanal gold miners to those from diamond and emerald miners working under similar conditions and with similar socioeconomic status and risks of infectious disease. Mercury-exposed gold miners had higher prevalence of detectable ANA and ANoA and higher titers of ANA and ANoA as compared to diamond and emerald miners with no occupational mercury exposure. Also, mercury-exposed gold-miners with detectable ANA or ANoA in serum had significantly higher concentrations of pro-inflammatory cytokines IL-1β, TNF-α, and IFN-γ in serum as compared to the diamond and emerald miners. This study provides further evidence that mercury exposure may lead to autoimmune dysfunction and systemic inflammation in affected populations.
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影响因子：
9.8
作者：
Dolbec, J;Mergler, D;Lucotte, M
通讯作者：
Lucotte, M
DOI：
10.1080/09603120600734147
发表时间：
2006-08-01
影响因子：
3.2
作者：
Alves, Maria Francinaire A.;Fraiji, Nelson A.;Cordeiro, George W. O.
通讯作者：
Cordeiro, George W. O.
影响因子：
8.3
作者：
Crompton, P;Ventura, AM;Silbergeld, E
通讯作者：
Silbergeld, E
影响因子：
11.4
作者：
Dominique, Yannick;Muresan, Bogdan;Boudou, Alain
通讯作者：
Boudou, Alain
影响因子：
56.9
作者：
BAKIR, F;DAMLUJI, SF;DOHERTY, RA
通讯作者：
DOHERTY, RA