Anatomical and functional dichotomy of ocular itch and pain.
Anatomical and functional dichotomy of ocular itch and pain.
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DOI：
10.1038/s41591-018-0083-x
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发表时间：
2018-08
期刊：
影响因子：
82.9
通讯作者：
Liu Q
中科院分区：
文献类型：
--
作者：
Huang CC;Yang W;Guo C;Jiang H;Li F;Xiao M;Davidson S;Yu G;Duan B;Huang T;Huang AJW;Liu Q
Itch and pain are refractory symptoms of many ocular conditions. Ocular itch is generated mainly in the conjunctiva, and is absent from the cornea. In contrast, most ocular pain arises from the cornea. However, the underlying mechanisms remain unknown. Using genetic axonal tracing approaches, we discovered distinct sensory innervation patterns between the conjunctiva and cornea. Further genetic and functional analyses in rodent models demonstrate that a subset of conjunctival-selective sensory fibers marked by MrgprA3 expression, rather than corneal sensory fibers, mediates ocular itch. Importantly, the actions of both histamine and non-histamine pruritogens converge onto this unique subset of conjunctiva sensory fibers, and enable them to play a key role in mediating itch associated with allergic conjunctivitis. This is distinct from skin itch in which discrete populations of sensory neurons co-operate to carry itch. Finally, we provide a proof-of-concept that selective silencing of conjunctiva itch-sensing fibers by pruritogen-mediated entry of sodium channel blocker QX-314 is a feasible therapeutic strategy to treat ocular itch in mice. Itch-sensing fibers also innervate the human conjunctiva,and allow pharmacological silence using QX-314.Our results cast new light on the neural mechanisms of ocular itch and open a new avenue for developing therapeutic strategies.
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DOI：
10.1523/jneurosci.3509-12.2012
发表时间：
2012-10-17
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Liu Q;Sikand P;Ma C;Tang Z;Han L;Li Z;Sun S;LaMotte RH;Dong X
通讯作者：
Dong X
DOI：
10.1159/000099253
发表时间：
2007-01-01
期刊：
Chemical immunology and allergy
影响因子：
--
作者：
Cursiefen, Claus
通讯作者：
Cursiefen, Claus
影响因子：
64.8
作者：
McNeil, Benjamin D.;Pundir, Priyanka;Meeker, Sonya;Han, Liang;Undem, Bradley J.;Kulka, Marianna;Dong, Xinzhong
通讯作者：
Dong, Xinzhong
影响因子：
25
作者：
Han, Liang;Ma, Chao;Liu, Qin;Weng, Hao-Jui;Cui, Yiyuan;Tang, Zongxiang;Kim, Yushin;Nie, Hong;Qu, Lintao;Patel, Kush N.;Li, Zhe;McNeil, Benjamin;He, Shaoqiu;Guan, Yun;Xiao, Bo;LaMotte, Robert H.;Dong, Xinzhong
通讯作者：
Dong, Xinzhong
影响因子：
7.4
作者：
BEUERMAN, RW;TANELIAN, DL
通讯作者：
TANELIAN, DL