Proton-counting radiography for proton therapy: a proof of principle using CMOS APS technology.
Proton-counting radiography for proton therapy: a proof of principle using CMOS APS technology.
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DOI：
10.1088/0031-9155/59/11/2569
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发表时间：
2014-06-07
影响因子：
3.5
通讯作者：
Evans PM
中科院分区：
文献类型：
--
作者：
Poludniowski G;Allinson NM;Anaxagoras T;Esposito M;Green S;Manolopoulos S;Nieto-Camero J;Parker DJ;Price T;Evans PM
尽管早期认识到质子成像的潜力，以协助质子治疗的方式仍然从临床实践中删除，与各种方法的发展。对于质子计数射线照相应用，如计算机断层扫描（CT），水等效路径长度（WEPL），每个质子已经通过成像对象的旅行必须推断。通常，基于闪烁器的技术已用于各种能量/距离望远镜设计。在这里，我们提出了一个非常不同的替代方案，使用抗辐射CMOS有源像素传感器（APS）技术。这种传感器分辨治疗射束中的单个质子的通过的能力先前尚未示出。在这里，使用36 MeV回旋加速器束（伯明翰大学回旋加速器，伯明翰，英国）和200 MeV临床放射治疗束（iThemba实验室，开普敦，SA）证明了这种能力。通过多个CMOS层跟踪单个质子的可行性也证明了使用两层堆叠的传感器。这种解决方案的主要优点是像素化传感器固有的事件的空间歧视，结合质子的范围和剩余能量的信息的潜在提供。在开发一个实用的系统的挑战进行了讨论。
Despite the early recognition of the potential of proton imaging to assist proton therapy the modality is still removed from clinical practice, with various approaches in development. For proton-counting radiography applications such as Computed Tomography (CT), the Water-Equivalent-Path-Length (WEPL) that each proton has travelled through an imaged object must be inferred. Typically, scintillator-based technology has been used in various energy/range telescope designs. Here we propose a very different alternative of using radiation-hard CMOS Active Pixel Sensor (APS) technology. The ability of such a sensor to resolve the passage of individual protons in a therapy beam has not been previously shown. Here, such capability is demonstrated using a 36 MeV cyclotron beam (University of Birmingham Cyclotron, Birmingham, UK) and a 200 MeV clinical radiotherapy beam (iThemba LABS, Cape Town, SA). The feasibility of tracking individual protons through multiple CMOS layers is also demonstrated using a two-layer stack of sensors. The chief advantages of this solution are the spatial discrimination of events intrinsic to pixelated sensors, combined with the potential provision of information on both the range and residual energy of a proton. The challenges in developing a practical system are discussed.
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DOI：
10.1016/j.nima.2004.03.108
发表时间：
2004-06-01
影响因子：
1.4
作者：
Sanchez-Crespo, A;Kerek, A;Végh, J
通讯作者：
Végh, J
DOI：
10.1016/j.nima.2012.04.029
发表时间：
2013-01-21
期刊：
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment
影响因子：
--
作者：
Sadrozinski HF;Johnson RP;Macafee S;Plumb A;Steinberg D;Zatserklyaniy A;Hurley VB;Schulte R
通讯作者：
Schulte R
影响因子：
19.7
作者：
WILSON, RR
通讯作者：
WILSON, RR
影响因子：
3.8
作者：
Schneider, U;Besserer, J;Kaser-Hotz, B
通讯作者：
Kaser-Hotz, B
影响因子：
3.2
作者：
CORMACK, AM
通讯作者：
CORMACK, AM