Multifunctional nanomedicine with silica: Role of silica in nanoparticles for theranostic, imaging, and drug monitoring.
Multifunctional nanomedicine with silica: Role of silica in nanoparticles for theranostic, imaging, and drug monitoring.
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DOI：
10.1016/j.jcis.2018.02.053
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发表时间：
2018-07-01
影响因子：
9.9
通讯作者：
Jokerst JV
中科院分区：
文献类型：
--
作者：
Chen F;Hableel G;Zhao ER;Jokerst JV
无需大手术即可进入人体诊断和治疗疾病的多功能纳米医学的想法是纳米材料科学家长期以来的梦想。纳米材料显示出散装材料所没有的令人难以置信的特性，但在单一材料上实现多功能仍然具有挑战性。在纳米尺度上集成多种类型的材料对于多功能纳米医学设备的成功至关重要。在这里，我们描述了二氧化硅纳米颗粒作为多功能纳米器件工具的优势。二氧化硅纳米粒子由于其生物相容性、可降解性、可调节的形态和易于修饰而在药物递送方面得到了深入研究。此外，二氧化硅纳米粒子可以与其他材料集成以获得更多功能并实现成像应用的治疗诊断能力和多模态。在这篇综述中，我们将首先将二氧化硅纳米粒子的特性与其他众所周知的生物应用纳米材料的特性进行比较，并描述合成和集成二氧化硅纳米粒子的典型路线。然后，我们将重点介绍使用二氧化硅纳米粒子的治疗诊断和多模态成像应用，特别关注治疗分子的实时监测。最后，我们将介绍二氧化硅基纳米颗粒在医学中未来工作的挑战和前景。
The idea of multifunctional nanomedicine that enters the human body to diagnose and treat disease without major surgery is a long-standing dream of nanomaterials scientists. Nanomaterials show incredible properties that are not found in bulk materials, but achieving multi-functionality on a single material remains challenging. Integrating several types of materials at the nano-scale is critical to the success of multifunctional nanomedicine device. Here, we describe the advantages of silica nanoparticles as a tool for multifunctional nano-devices. Silica nanoparticles have been intensively studied in drug delivery due to their biocompatibility, degradability, tunable morphology, and ease of modification. Moreover, silica nanoparticles can be integrated with other materials to obtain more features and achieve theranostic capabilities and multimodality for imaging applications. In this review, we will first compare the properties of silica nanoparticles with other well-known nanomaterials for bio-applications and describe typical routes to synthesize and integrate silica nanoparticles. We will then highlight theranostic and multimodal imaging application that use silica-based nanoparticles with a particular interest in real-time monitoring of therapeutic molecules. Finally, we will present the challenges and perspective on future work with silica-based nanoparticles in medicine.
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影响因子：
2.3
作者：
Agostini, Alessandro;Mondragon, Laura;Coll, Carmen;Aznar, Elena;Marcos, M. Dolores;Martinez-Manez, Ramon;Sancenon, Felix;Soto, Juan;Perez-Paya, Enrique;Amoros, Pedro
通讯作者：
Amoros, Pedro
影响因子：
9.5
作者：
Chen F;Zhao E;Kim T;Wang J;Hableel G;Reardon PJT;Ananthakrishna SJ;Wang T;Arconada-Alvarez S;Knowles JC;Jokerst JV
通讯作者：
Jokerst JV
影响因子：
4.9
作者：
Alexis F;Pridgen E;Molnar LK;Farokhzad OC
通讯作者：
Farokhzad OC
上转换纳米颗粒：设计、纳米化学及其在治疗诊断学中的应用
影响因子：
62.1
作者：
Chen, Guanying;Qju, Hailong;Prasad, Paras N.;Chen, Xiaoyuan
通讯作者：
Chen, Xiaoyuan
影响因子：
3.9
作者：
Bagwe, RP;Hilliard, LR;Tan, WH
通讯作者：
Tan, WH