Dual enzyme-triggered controlled release on capped nanometric silica mesoporous supports.
Dual enzyme-triggered controlled release on capped nanometric silica mesoporous supports.
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DOI：
10.1002/open.201200003
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发表时间：
2012-02
期刊：
影响因子：
2.3
通讯作者：
Amoros, Pedro
中科院分区：
文献类型：
--
作者：
Agostini, Alessandro;Mondragon, Laura;Coll, Carmen;Aznar, Elena;Marcos, M. Dolores;Martinez-Manez, Ramon;Sancenon, Felix;Soto, Juan;Perez-Paya, Enrique;Amoros, Pedro
近年来，配备有“分子门”的纳米杂化材料的发展引起了人们的极大关注，并被广泛探索，所述“分子门”显示出在施加外部触发时释放目标捕获的客人的能力。[1]这些纳米器件由两个亚单元组成，即合适的支撑体和接枝在支架表面上的某些帽实体。[2]载体用作合适的储存器，其中可以储存某些化学品，而外表面中接枝的分子充当“门”，并且可以随意控制捕获分子的释放。介孔二氧化硅纳米粒子（MSN）由于其独特的性质，如大负载量、生物相容性、高比表面积和众所周知的功能化过程，被广泛用作载体。[3]此外，门控MSN最近已被用于通过使用几种物理和化学触发器来开发按命令递送纳米器件。例如，已经描述了MSN利用光、[4]氧化还原反应[5]和pH变化[6]显示控释特征。相比之下，能够递送由生物分子触发的货物的门控纳米材料是稀缺的，尽管一些使用抗原的说明性实例是有用的。
The development of nanoscopic hybrid materials equipped with “molecular gates” showing the ability of releasing target entrapped guests upon the application of an external trigger has attracted great attention and has been extensively explored during recent years.[1] These nanodevices are composed of two subunits, namely, a suitable support and certain capping entities grafted on the surface of the scaffolding.[2] The support is used as a suitable reservoir in which certain chemicals can be stored whereas the molecules grafted in the outer surface act as a “gate” and can control the release of the entrapped molecules at will. Both components are carefully selected and arranged in order to achieve a wide range of required functionalities.As support, mesoporous silica nanoparticles (MSN) have been widely used due to their unique properties, such as large load capacity, biocompatibility, high surface area and wellknown functionalization procedures.[3] Moreover, gated MSN have recently been used for the development of on-command delivery nanodevices by using several physical and chemical triggers. For instance, MSN displaying controlled-release features with the use of light,[4] redox reactions,[5] and pH changes [6] have been described. In contrast, gated nanomaterials able to deliver the cargo triggered by biomolecules are scarce although some illustrative examples that use antigen–
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影响因子：
16.6
作者：
Climent, Estela;Martinez-Manez, Ramon;Amoros, Pedro
通讯作者：
Amoros, Pedro
影响因子：
15
作者：
BECK, JS;VARTULI, JC;SCHLENKER, JL
通讯作者：
SCHLENKER, JL
影响因子：
15
作者：
Angelos, Sarah;Yang, Ying-Wei;Zink, Jeffrey I.
通讯作者：
Zink, Jeffrey I.
影响因子：
29.4
作者：
Aznar, Elena;Casasus, Rosa;Martinez-Manez, Ramon
通讯作者：
Martinez-Manez, Ramon
影响因子：
15
作者：
Angelos, Sarah;Khashab, Niveen M.;Zink, Jeffrey I.
通讯作者：
Zink, Jeffrey I.