Potential endocrine correlation with exposure to domoic acid in Southern Right Whale (Eubalaena australis) at the Península Valdés breeding ground

Potential endocrine correlation with exposure to domoic acid in Southern Right Whale (Eubalaena australis) at the Península Valdés breeding ground
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瓦尔德斯半岛繁殖地的南露脊鲸(Eubalaena australis)与暴露于软骨藻酸的潜在内分泌相关性

DOI:
10.1007/s00442-021-05078-4
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发表时间:
2022
期刊:
影响因子:
2.7
通讯作者:
Buck, C. Loren
Buck, C. Loren
中科院分区:
环境科学与生态学2区
文献类型:
--
作者:
D’Agostino, Valeria C.;Fernández Ajó, Alejandro;Degrati, Mariana;Krock, Bernd;Hunt, Kathleen E.;Uhart, Marcela M.;Buck, C. Loren

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在阿根廷瓦尔德斯半岛(PV)附近的沃茨,南露脊鲸(SRW,Eubalaena australis)偶尔会接触到软骨藻酸(DA),这是一种由伪菱形藻属硅藻产生的神经毒素。软骨藻酸在海洋哺乳动物中的毒性可引起胃肠道和神经系统的临床症状,血液学和内分泌变量的改变,在极端情况下可能是致命的。在这项研究中,我们验证了一种酶免疫测定法,以量化2013年至2018年PV中活的和死的搁浅鲸鱼的16个SRW粪便样本中的粪便糖皮质激素代谢物(fGCm),并评估了与DA暴露相关的fGCm水平。总体而言,与粪便DA水平不可检测的SRW(n= 13)相比,粪便DA水平可检测的SRW(n= 3)中的fGCm水平显著较低。在活的哺乳期雌性动物中观察到最高的粪便DA,与研究的其他哺乳期雌性动物相比,其fGCm较低。最高的fGCm是在一只哺乳期雌性动物中观察到的,其DA检测不到;有趣的是,在样本采集时,该雌性动物与两只小牛一起出现,这在该物种中是极不寻常的。虽然这些非常罕见的繁殖季节粪便样本的样本量非常小,但我们的研究提供了暴露于环境神经毒素(如DA)的鲸鱼肾上腺可能发生变化的证据。
In waters off Península Valdés (PV), Argentina, southern right whales (SRW,Eubalaena australis) are occasionally exposed to domoic acid (DA), a neurotoxin produced by diatoms of the genusPseudo-nitzschia. Domoic acid toxicity in marine mammals can cause gastrointestinal and neurological clinical signs, alterations in hematologic and endocrine variables, and can be fatal in extreme cases. In this study, we validated an enzyme immunoassay to quantify fecal glucocorticoid metabolites (fGCm) in 16 SRW fecal samples from live and dead stranded whales in PV from 2013 to 2018 and assessed fGCm levels associated with DA exposure. Overall, fGCm levels were significantly lower in SRWs with detectable fecal DA (n= 3) as compared to SRWs with undetectable fecal DA levels (n= 13). The highest fecal DA was observed in a live lactating female, which had low fGCm compared to the other lactating females studied. The highest fGCm was observed in a lactating female with undetectable DA; interestingly, at the time of sample collection, this female was sighted with two calves, an extremely unusual occurrence in this species. Though the sample size of these exceptionally rare breeding-season fecal samples was unavoidably small, our study provides evidence of potential adrenal alterations in whales exposed to an environmental neurotoxin such as DA.
DOI: --
发表时间: --
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影响因子: --
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C. Gabriele;L. Taylor;K. Burek Huntington;C. Buck;K. Hunt;K. Lefebvre;C. Lockyer;Carley L. Lowe;J. Moran;A. Murphy;Matthew Rogers;S. Trumble;S. Raverty
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发表时间: 2000-01-06
期刊: NATURE
影响因子: 64.8
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Scholin, CA;Gulland, F;Van Dolah, FM
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DOI: 10.1006/gcen.2000.7557
发表时间: 2000-12-01
影响因子: 2.7
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通讯作者: Gulland, Frances M. D.
南露脊鲸 Eubalaena australis 可能正在哺乳非后代
DOI: --
发表时间: 2015
期刊:
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作者:
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