UVA-Triggered Drug Release and Photo-Protection of Skin.

UVA-Triggered Drug Release and Photo-Protection of Skin.
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DOI:
10.3389/fcell.2021.598717
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发表时间:
2021
影响因子:
5.5
通讯作者:
Zhong JL
Zhong JL
中科院分区:
生物学2区
文献类型:
--
作者:
Karisma VW;Wu W;Lei M;Liu H;Nisar MF;Lloyd MD;Pourzand C;Zhong JL

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光作为触发给药系统(DDS)的一种刺激,由于其内在的空间和时间可调的特性而引起了人们的特别关注。紫外线A (UVA)辐射最近被用作外部光刺激的来源,使用“开关开关”程序来控制药物的释放。这篇综述讨论了UVA辐射作为光控药物通过光异构化、光裂解、光交联和光诱导重排从一系列光响应和光稳定的纳米结构中释放的光源的潜力。除了临床应用外,我们还将概述最近开发的用于光疗和皮肤光保护的uva反应性药物释放方法。
Light has attracted special attention as a stimulus for triggered drug delivery systems (DDS) due to its intrinsic features of being spatially and temporally tunable. Ultraviolet A (UVA) radiation has recently been used as a source of external light stimuli to control the release of drugs using a “switch on- switch off” procedure. This review discusses the promising potential of UVA radiation as the light source of choice for photo-controlled drug release from a range of photo-responsive and photolabile nanostructures via photo-isomerization, photo-cleavage, photo-crosslinking, and photo-induced rearrangement. In addition to its clinical use, we will also provide here an overview of the recent UVA-responsive drug release approaches that are developed for phototherapy and skin photoprotection.
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