Ultrasmall, Water-Soluble Magnetite Nanoparticles with High Relaxivity for Magnetic Resonance Imaging.
Ultrasmall, Water-Soluble Magnetite Nanoparticles with High Relaxivity for Magnetic Resonance Imaging.
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DOI：
10.1021/jp907216g
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发表时间：
2009-12-10
期刊：
影响因子：
--
通讯作者：
Meade TJ
中科院分区：
文献类型：
--
作者：
Hu F;MacRenaris KW;Waters EA;Liang T;Schultz-Sikma EA;Eckermann AL;Meade TJ
以二甘醇为溶剂，采用一锅法合成了超小（3、4、5和6 nm）水溶性Fe 3 O 4磁性纳米粒子。流体动力学尺寸和弛豫时间测量没有显示粒子聚集时，Fe 3 O 4纳米粒子分散在磷酸盐缓冲盐水，胎牛血清，或小牛血清1周。此外，新的Fe 3 O 4纳米颗粒耐受高盐浓度（≤1 M NaCl）和5至11的宽pH范围。通过配体交换反应用聚（乙二醇）双（羧甲基）醚（HOOC-PEG-COOH，600 g/mol）对纳米颗粒进行表面改性。研究了PEG修饰对Fe 3 O 4纳米粒子的磁化强度和弛豫率的影响，结果表明PEG修饰后横向弛豫率的增加可能是由于每个纳米粒子周围缓慢扩散的水的体积增加。体外实验表明，DEG和PEG包覆的Fe 3 O 4纳米粒子对NIH/3 T3细胞活力的影响很小。
Ultrasmall (3, 4, 5, and 6 nm), water-soluble Fe3O4 magnetic nanoparticles were synthesized in diethylene glycol (DEG) via a facile one-pot reaction. Hydrodynamic size and relaxation time measurements did not show particle aggregation when Fe3O4 nanoparticles were dispersed in phosphate buffered saline, fetal bovine serum, or calf bovine serum for 1 week. Furthermore, the new Fe3O4 nanoparticles tolerated high salt concentrations (≤1 M NaCl) and a wide pH range from 5 to 11. Surface modification of the nanoparticles with poly(ethylene glycol) bis(carboxymethyl) ether (HOOC-PEG-COOH, 600 g/mol) was accomplished through a ligand-exchange reaction. The effects of PEG modification on magnetization and relaxivity of the Fe3O4 nanoparticles were investigated, and the results indicate that the increase in transverse relaxivity after PEG modification may be due to the increased volume of slowly diffusing water surrounding each nanoparticle. In vitro experiments showed that the DEG- and PEG-coated Fe3O4 nanoparticles have little effect on NIH/3T3 cell viability.
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