The radial diffusivity and magnetization transfer pool size ratio are sensitive markers for demyelination in a rat model of type III multiple sclerosis (MS) lesions.
The radial diffusivity and magnetization transfer pool size ratio are sensitive markers for demyelination in a rat model of type III multiple sclerosis (MS) lesions.
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DOI：
10.1016/j.neuroimage.2013.02.034
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发表时间：
2013-07-01
期刊：
影响因子：
5.7
通讯作者：
Gochberg, Daniel F.
中科院分区：
文献类型：
--
作者：
Janve, Vaibhav A.;Zu, Zhongliang;Yao, Song-Yi;Li, Ke;Zhang, Fang Lin;Wilson, Kevin J.;Ou, Xiawei;Does, Mark D.;Subramaniam, Sriram;Gochberg, Daniel F.
关键词：
确定定量磁共振成像的生物物理敏感性和特异性对于开发神经退行性变的有效成像指标至关重要。在这些指标中，定量磁化转移 (qMT) 成像的表观池大小比 (PSR) 和扩散张量成像 (DTI) 的径向扩散率 (RD) 均与髓磷脂密度和完整性的组织学测量相关。然而，它们对定量髓磷脂检测的相对敏感性尚不清楚。在这项研究中，我们将亚体素组织结构的高分辨率定量磁共振成像测量与脂多糖（LPS）介导的多发性硬化症动物模型中相应的定量髓磷脂组织学相关联。具体来说，我们在 III 型少突胶质细胞病动物模型系统中获得了定量磁化转移 (qMT) 和扩散张量成像 (DTI) 指标（在同一组织样本上），该系统缺乏明显的淋巴细胞浸润，该系统之前从未用定量 MRI 检查过。我们发现，qMT 测量的表观池大小比 (PSR) 显示出与髓磷脂含量的组织学测量值最强的相关性。 DTI 测量的 RD 显示出第二强的相关性，而其他 DTI 和松弛参数（例如纵向松弛率 (R1f) 或分数各向异性 (FA)）显示与髓磷脂含量的相关性相当弱。
Determining biophysical sensitivity and specificity of quantitative magnetic resonance imaging is essential to develop effective imaging metrics of neurodegeneration. Among these metrics apparent pool size ratio (PSR) from quantitative magnetization transfer (qMT) imaging and radial diffusivity (RD) from diffusion tensor imaging (DTI) are both known to relate to histological measure of myelin density and integrity. However their relative sensitivities towards quantitative myelin detection are unknown. In this study, we correlated high-resolution quantitative magnetic resonance imaging measures of subvoxel tissue structures with corresponding quantitative myelin histology in a lipopolysacharide (LPS) mediated animal model of MS. Specifically, we acquired quantitative magnetization transfer (qMT) and diffusion tensor imaging (DTI) metrics (on the same tissue sample) in an animal model system of type III oligodendrogliopathy which lacked prominent lymphocytic infiltration, a system that had not been previously examined with quantitative MRI. We find that the qMT measured apparent pool size ratio (PSR) showed the strongest correlation with a histological measure of myelin content. DTI measured RD showed the next strongest correlation, and other DTI and relaxation parameters (such as the longitudinal relaxation rate (R1f) or fractional anisotropy (FA)) showed considerably weaker correlations with myelin content.
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