Heterogeneity in oligodendroglia: Is it relevant to mouse models and human disease?
Heterogeneity in oligodendroglia: Is it relevant to mouse models and human disease?
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DOI：
10.1002/jnr.23900
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发表时间：
2016-12
影响因子：
4.2
通讯作者：
Wood TL
中科院分区：
文献类型：
--
作者：
Ornelas IM;McLane LE;Saliu A;Evangelou AV;Khandker L;Wood TL
有许多证据表明，OPC和少突胶质细胞群体在中枢神经系统是异质性的基础上，他们的发展起源，以及从形态学和分子标准。这些区别是否反映了功能的异质性尚不清楚，并一直是相当多的辩论的主题。最近的研究结果，特别是从敲除小鼠模型提供了新的证据，髓鞘形成表型的区域变化，特别是脑和脊髓之间。这些数据提高了这些区域中的少突胶质细胞具有不同的功能能力和/或补偿特定基因丢失的能力的可能性。本综述的目的是简要回顾少突胶质细胞异质性的证据，然后提出转基因和脱髓鞘小鼠模型的数据表明在中枢神经系统髓鞘形成，脱髓鞘和髓鞘再生的功能异质性，最后，讨论这些发现对人类疾病的影响。
There are many lines of evidence indicating that OPC and oligodendrocyte populations in the CNS are heterogeneous based on their developmental origins as well as from morphological and molecular criteria. Whether these distinctions reflect functional heterogeneity is less clear and has been the subject of considerable debate. Recent findings particularly from knockout mouse models have provided new evidence for regional variations in myelination phenotypes, particularly between brain and spinal cord. These data raise the possibility that oligodendrocytes in these regions have different functional capacities and/or ability to compensate for loss of a specific gene. The goal of this review is to briefly revisit the evidence for oligodendrocyte heterogeneity and then to present data from transgenic and demyelinating mouse models suggesting functional heterogeneity in myelination, demyelination and remyelination in the CNS and finally, to discuss the implications of these findings for human diseases.
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影响因子：
11.2
作者：
Chang, Ansi;Staugaitis, Susan M.;Dutta, Ranjan;Batt, Courtney E.;Easley, Kathryn E.;Chomyk, Anthony M.;Yong, V. Wee;Fox, Robert J.;Kidd, Grahame J.;Trapp, Bruce D.
通讯作者：
Trapp, Bruce D.
影响因子：
6.4
作者：
Albert, Monika;Antel, Jack;Stadelmann, Christine
通讯作者：
Stadelmann, Christine
影响因子：
5.3
作者：
Bercury, Kathryn K.;Dai, JinXiang;Macklin, Wendy B.
通讯作者：
Macklin, Wendy B.
DOI：
10.1111/j.1365-2990.1978.tb00528.x
发表时间：
1978-01-01
影响因子：
5
作者：
BLAKEMORE, WF
通讯作者：
BLAKEMORE, WF
影响因子：
5.3
作者：
Duncan, Ian D.;Radcliff, Abigail B.
通讯作者：
Radcliff, Abigail B.