Inherited and acquired disorders of myelin: The underlying myelin pathology.
Inherited and acquired disorders of myelin: The underlying myelin pathology.
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DOI：
10.1016/j.expneurol.2016.04.002
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发表时间：
2016-09
影响因子：
5.3
通讯作者：
Radcliff, Abigail B.
中科院分区：
文献类型：
--
作者：
Duncan, Ian D.;Radcliff, Abigail B.
髓鞘再生是人类髓鞘疾病的主要治疗目标，用于恢复脱髓鞘轴突的功能并提供神经保护。促进这种修复过程的目标疾病是多种多样的，并且数量在增加。它们的范围主要从遗传的、炎症的到毒性的。为了将髓鞘再生策略应用于这些疾病，有必要了解髓鞘损伤是由髓鞘或少突胶质细胞的原发性攻击引起的，还是两者兼有，以及这些是否确实导致髓鞘分解和脱髓鞘。在某些疾病中，髓鞘异常明显，但不发生脱髓鞘。本综述探讨了髓磷脂病理存在的人类和动物疾病的范围，并着重于定义每种疾病的髓磷脂变化及其原因，以帮助确定它们是否为髓磷脂修复治疗的靶点。我们回顾了人类和动物中枢神经系统的髓磷脂疾病。髓鞘损伤是由对少突胶质细胞或髓鞘的原发性攻击引起的。所有主要类型的疾病都可以影响中枢神经系统髓磷脂。髓鞘空泡是常见的，但并不总是导致脱髓鞘。
Remyelination is a major therapeutic goal in human myelin disorders, serving to restore function to demyelinated axons and providing neuroprotection. The target disorders that might be amenable to the promotion of this repair process are diverse and increasing in number. They range primarily from those of genetic, inflammatory to toxic origin. In order to apply remyelinating strategies to these disorders, it is essential to know whether the myelin damage results from a primary attack on myelin or the oligodendrocyte or both, and whether indeed these lead to myelin breakdown and demyelination. In some disorders, myelin sheath abnormalities are prominent but demyelination does not occur. This review explores the range of human and animal disorders where myelin pathology exists and focusses on defining the myelin changes in each and their cause, to help define whether they are targets for myelin repair therapy. We reviewed myelin disorders of the CNS in humans and animals. Myelin damage results from primary attack on the oligodendrocyte or myelin sheath. All major categories of disease can affect CNS myelin. Myelin vacuolation is common, yet does not always result in demyelination.
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影响因子：
12.7
作者：
Bradl M;Lassmann H
通讯作者：
Lassmann H
影响因子：
11.2
作者：
Breij, Esther C. W.;Brink, Bianca P.;Boe, Lars
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Boe, Lars
DOI：
10.1111/j.1365-2990.1978.tb00528.x
发表时间：
1978-01-01
影响因子：
5
作者：
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通讯作者：
BLAKEMORE, WF
影响因子：
6.2
作者：
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通讯作者：
Rosenberg, Paul A.
影响因子：
11.2
作者：
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通讯作者：
Minetti, Carlo