Novel drugs targeting hypertension revisited.
Novel drugs targeting hypertension revisited.
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重新审视针对高血压的新药。
DOI：
10.1097/fjc.0b013e3181f0d63f
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发表时间：
2010
影响因子：
3
通讯作者：
Booz,GeorgeW
中科院分区：
文献类型：
--
作者：
Booz,GeorgeW
三年前，《心血管药理学杂志》发表了一系列针对高血压的新药的综述。在本期和下一期中，出现了一系列文章，讨论了药物开发的4个新领域，这些领域近年来已经发展，与治疗高血压和其他心血管疾病有关。不幸的是，对这些药物的需求一如既往地大。根据美国心脏协会的最新报告，美国每3名成年人中就有1人患有高血压，表现为收缩压≥ 140 mm Hg或舒张压≥ 90 mm Hg，正在服用降压药，或在2次单独就诊时被医生或医疗保健专业人员告知患有高血压。1 2010年，高血压的直接和间接费用估计为766亿美元。2006年的最新统计数据显示，高血压导致的总死亡率为17.8：白色男性为15.6;黑人男性为51.1;白色女性为14.3;黑人女性为37.7。血压> 140/90 mm Hg在大约69%的首次心脏病发作者、77%的首次中风者和74%的充血性心力衰竭者中发现。总体而言，近75%的心血管疾病合并症成人患有高血压，这与总体预期寿命较短有关。令人担忧的是，高血压前期和高血压在儿童和8- 17岁青少年中的发病率正在增加，部分原因是我们目前面临的肥胖流行病。收缩期高血压控制不佳仍然是治疗高血压的主要问题，并进一步降低了因终末器官损伤而导致的心血管疾病的风险。2003年至2006年的最新统计数据显示，在高血压患者中，55.9%的人没有得到控制。因此，需要新的药物发现来治疗大多数患有高血压的人。对新型抗高血压药物的额外需求来自糖尿病和肥胖症的增长率，以及人口老龄化，所有这些因素都与高血压有关。2
Three years ago, The Journal of Cardiovascular Pharmacology published a review series on novel drugs targeting hypertension. In the current issue and the next one, a series of articles appear that discuss 4 new areas for drug development, which have evolved in recent years and have relevance for treating hypertension and other cardiovascular diseases. Unfortunately, the need for such drugs is as great as ever. According to the most recent report of the American Heart Association, 1 in 3 adults in the United States has high blood pressure, as evidenced by having systolic blood pressure≥ 140 mm Hg or diastolic blood pressure≥ 90 mm Hg, being on antihypertensive medicine, or being told by their doctor or health care professional in 2 separate visits that they have high blood pressure. 1 For 2010, the estimated direct and indirect cost for high blood pressure is estimated to be $76.6 billion. The most recent statistics available from 2006 show that the overall death rate due to high blood pressure was 17.8: among white men, 15.6; black men, 51.1; white women, 14.3; and black women, 37.7. Blood pressure> 140/90 mm Hg is found in approximately 69% of those who have a first heart attack, 77% of those who have a first stroke, and 74% of those who have congestive heart failure. Overall, almost 75% of adults with cardiovascular disease comorbidities have hypertension, which is associated with a shorter overall life expectancy. Alarmingly, rates of prehypertension and hypertension are increasing among children and 8-to 17-years-old adolescents due in part to the obesity epidemic we currently face.Poor control of systolic hypertension remains a principal problem in treating hypertension and further compromises the risk of cardiovascular disease due to end organ damage. The latest statistics from 2003 to 2006 reveal that of those with high blood pressure, 55.9% do not have it under control. 1 Therefore, new drug discoveries are needed to treat the majority of individuals who have high blood pressure. An additional need for novel antihypertensive drugs comes from the growing rates of diabetes and obesity, as well as an aging population, all factors that are associated with high blood pressure. 2
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4.6
作者：
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通讯作者：
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DOI：
--
发表时间：
1999
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Harari,OA;McHale,JF;Marshall,D;Ahmed,S;Brown,D;Askenase,PW;Haskard,DO
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Haskard,DO
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DOI：
--
发表时间：
2013
期刊：
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作者：
Toyoshima;S.;Obata;Y.;Wakamatsu;E. and Abe;R.
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高频率的过敏原特异性 CD8+ Tc1 细胞与小鼠对接触敏化剂三硝基苯的免疫反应有关
影响因子：
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作者：
Stefan F. Martin;V. Delattre;C. Leicht;H. Weltzien;J. Simon
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尖端技术：抗原刺激后静息记忆 CD8 T 细胞立即分泌 RANTES 1
DOI：
10.4049/jimmunol.170.4.1615
发表时间：
2003
期刊：
The Journal of Immunology
影响因子：
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作者：
T. Walzer;A. Marçais;F. Saltel;C. Bella;P. Jurdic;J. Marvel
通讯作者：
J. Marvel