Predicting later-life outcomes of early-life exposures.
Predicting later-life outcomes of early-life exposures.
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DOI：
10.1289/ehp.1204934
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发表时间：
2012-10
影响因子：
10.4
通讯作者：
Rogers JM
中科院分区：
文献类型：
--
作者：
Boekelheide K;Blumberg B;Chapin RE;Cote I;Graziano JH;Janesick A;Lane R;Lillycrop K;Myatt L;States JC;Thayer KA;Waalkes MP;Rogers JM
背景：胎儿在子宫内暴露于应激源会导致以后的疾病。表观遗传机制很可能是早期生活事件的后期生活表达的介导者。目的：我们研究了对早期暴露导致的晚年疾病的理解的现状，以确定宫内和产后晚年疾病的指标，为未来的研究制定议程，并考虑这种新兴知识的风险评估影响。研究方法：这项审查是根据我们参加的国家研究理事会研讨会题为“使用在UNUS和产后指标预测健康结果以后的生活：国家的科学和研究建议”。我们采用案例研究的方法来强调早期营养不良和砷暴露对晚年生活的影响。讨论内容：表观基因组的环境敏感性被认为是一种适应机制，发育中的生物体通过这种机制调整其代谢和稳态系统以适应预期的子宫外环境。不适当的适应可能会产生不匹配，导致随后对疾病的易感性增加。出生前和出生后环境之间的营养不匹配，或早期生活中的肥胖源暴露，至少可以解释最近肥胖，2型糖尿病和心血管疾病发病率快速增加的部分原因。早期砷暴露也与晚年疾病有关，包括心血管疾病和癌症。结论：随着越来越多的证据将早期生活暴露与晚年疾病联系起来，需要新的策略将这种新兴的知识纳入健康保护实践。
Background: In utero exposure of the fetus to a stressor can lead to disease in later life. Epigenetic mechanisms are likely mediators of later-life expression of early-life events. Objectives: We examined the current state of understanding of later-life diseases resulting from early-life exposures in order to identify in utero and postnatal indicators of later-life diseases, develop an agenda for future research, and consider the risk assessment implications of this emerging knowledge. Methods: This review was developed based on our participation in a National Research Council workshop titled “Use of in Utero and Postnatal Indicators to Predict Health Outcomes Later in Life: State of the Science and Research Recommendations.” We used a case study approach to highlight the later-life consequences of early-life malnutrition and arsenic exposure. Discussion: The environmental sensitivity of the epigenome is viewed as an adaptive mechanism by which the developing organism adjusts its metabolic and homeostatic systems to suit the anticipated extrauterine environment. Inappropriate adaptation may produce a mismatch resulting in subsequent increased susceptibility to disease. A nutritional mismatch between the prenatal and postnatal environments, or early-life obesogen exposure, may explain at least some of the recent rapid increases in the rates of obesity, type 2 diabetes, and cardiovascular diseases. Early-life arsenic exposure is also associated with later-life diseases, including cardiovascular disease and cancer. Conclusions: With mounting evidence connecting early-life exposures and later-life disease, new strategies are needed to incorporate this emerging knowledge into health protective practices.
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DOI：
10.1042/cs20110627
发表时间：
2012-07
期刊：
Clinical science (London, England : 1979)
影响因子：
--
作者：
Davis EF;Newton L;Lewandowski AJ;Lazdam M;Kelly BA;Kyriakou T;Leeson P
通讯作者：
Leeson P
影响因子：
6.6
作者：
Brown, Alan S.;Patterson, Paul H.
通讯作者：
Patterson, Paul H.
宫内生长限制后，新生儿的胞嘧啶甲基化失调。
影响因子：
3.7
作者：
Einstein F;Thompson RF;Bhagat TD;Fazzari MJ;Verma A;Barzilai N;Greally JM
通讯作者：
Greally JM
影响因子：
3.7
作者：
Chu T;Handley D;Bunce K;Surti U;Hogge WA;Peters DG
通讯作者：
Peters DG
DOI：
10.1093/toxsci/kfq103
发表时间：
2010-08
期刊：
Toxicological sciences : an official journal of the Society of Toxicology
影响因子：
--
作者：
Bruin JE;Gerstein HC;Holloway AC
通讯作者：
Holloway AC