Adipose extracellular matrix remodelling in obesity and insulin resistance.
Adipose extracellular matrix remodelling in obesity and insulin resistance.
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DOI：
10.1016/j.bcp.2016.05.005
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发表时间：
2016-11-01
影响因子：
5.8
通讯作者：
Kang, Li
中科院分区：
文献类型：
--
作者：
Lin, De;Chun, Tae-Hwa;Kang, Li
脂肪组织的细胞外基质(ECM)经历不断的重塑，以允许脂肪细胞及其前体细胞改变细胞的形状和功能，以适应营养提示。最近证实，细胞外基质成分及其修饰物在脂肪组织中的异常积累会导致肥胖相关的胰岛素抵抗，这是2型糖尿病的一个标志。在脂肪组织中表达的整合素和其他ECM受体(如CD44)已被证明调节胰岛素敏感性。众所周知，在肥胖进展过程中观察到脂肪组织扩张的低氧反应，这种低氧反应加速白色脂肪组织的纤维化和炎症。脂肪组织的扩张应该需要血管生成；然而，过度沉积的ECM限制了白色脂肪组织在肥胖时的血管生成反应。虽然最近的研究主要集中在脂肪组织扩张和重塑的代谢后果和机制上，但很少有人关注脂肪细胞周围ECM与其同源细胞表面受体之间的相互作用所起的作用。这篇综述将阐述目前已知的脂肪细胞外基质及其修饰物和细胞外基质受体在肥胖和胰岛素抵抗中所起的作用。了解脂肪组织中过度的ECM沉积如何恶化胰岛素敏感性，将为我们开发治疗胰岛素抵抗和2型糖尿病的新治疗策略提供线索。
The extracellular matrix (ECM) of adipose tissues undergoes constant remodelling to allow adipocytes and their precursor cells to change cell shape and function in adaptation to nutritional cues. Abnormal accumulation of ECM components and their modifiers in adipose tissues has been recently demonstrated to cause obesity-associated insulin resistance, a hallmark of type 2 diabetes. Integrins and other ECM receptors (e.g. CD44) that are expressed in adipose tissues have been shown to regulate insulin sensitivity. It is well understood that a hypoxic response is observed in adipose tissue expansion during obesity progression and that hypoxic response accelerates fibrosis and inflammation in white adipose tissues. The expansion of adipose tissues should require angiogenesis; however, the excess deposition of ECM limits the angiogenic response of white adipose tissues in obesity. While recent studies have focused on the metabolic consequences and the mechanisms of adipose tissue expansion and remodelling, little attention has been paid to the role played by the interaction between peri-adipocyte ECM and their cognate cell surface receptors. This review will address what is currently known about the roles played by adipose ECM, their modifiers, and ECM receptors in obesity and insulin resistance. Understanding how excess ECM deposition in the adipose tissue deteriorates insulin sensitivity would provide us hints to develop a new therapeutic strategy for the treatment of insulin resistance and type 2 diabetes.
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影响因子：
3.7
作者：
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发表时间：
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影响因子：
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