Association of the HLA-DQA1 and HLA-DQB1 Alleles in Type 2 Diabetes Mellitus and Diabetic Nephropathy in the Han Ethnicity of China.
Association of the HLA-DQA1 and HLA-DQB1 Alleles in Type 2 Diabetes Mellitus and Diabetic Nephropathy in the Han Ethnicity of China.
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中国汉族2型糖尿病和糖尿病肾病HLA-DQA1和HLA-DQB1等位基因的关联
DOI：
10.1155/2013/452537
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发表时间：
2013
影响因子：
4.3
通讯作者：
Chen LM
中科院分区：
文献类型：
--
作者：
Ma ZJ;Sun P;Guo G;Zhang R;Chen LM
HLA基因系统是人类基因组中最具多态性的区域之一。已报告了几个种族的HLA II类基因在T1 DM发病机制中的相关性。HLA II类基因与T2 DM的关联揭示了不一致的结果。此外，DN和HLA等位基因之间的相关性尚不清楚。采用特异性中分辨率分型探针对310例2型糖尿病患者（包括210例糖尿病肾病患者和100例非糖尿病肾病患者）和100例健康对照者进行DNA分型芯片检测。2型糖尿病组HLA-DQA 1等位基因频率（15.5%）和等位基因频率（16.6%）与对照组（8.5%）比较差异有显著性（P < 0.01）。DN组与非DN组HLA-DQA 1等位基因频率分别为6.9%和13.5%（P < 0.01），HLA-DQB 1等位基因频率分别为5.8%和14.5%（P < 0.01）。糖尿病病程和收缩压是DN的独立危险因素（OR值分别为2.277和1.366），而HLA-DQB 1等位基因对DN有保护作用（OR = 0.53，P < 0.05）。提示HLA-DQA 1 - 0301和HLA-DQA 1 - 0501等位基因是中国汉族T2 DM的易感性标志，HLA-DQB 1 - 0501等位基因与DN的保护作用相关。
HLA gene system is one of the most polymorphic regions of the human genome. The association of HLA class II genes in T1DM pathogenesis has been reported for several ethnicities. Associations of HLA class II genes with T2DM have revealed inconsistent results. Moreover, correlations between DN and HLA alleles remain unclear. We carried out DNA typing chip by specific medium resolution typing probes in 310 T2DM subjects (including 210 patients with DN and 100 patients without DN) in addition to 100 healthy controls. Differences were found between patients with T2DM and the control group in the frequencies of the HLA-DQA1∗0301 (15.5% versus 8.0%, P < 0.01) and the HLA-DQA1∗0501 alleles (16.6% versus 8.5%, P < 0.01). Differences were found between patients with DN and without DN in the frequencies of the HLA-DQA1∗0302 (6.9% versus 13.5%, P < 0.01) and HLA-DQB1∗0501 alleles (5.8% versus 14.5%, P < 0.01). Diabetes duration and systolic blood pressure were independent risk factors associated with DN (OR = 2.277 and 1.366, resp., P < 0.05), whereas the HLA-DQB1∗0501 llele had a protective effect on DN (OR = 0.53, P < 0.05). These data suggest the HLA-DQA1∗0301 and HLA-DQA1∗0501 alleles are markers of susceptibility for T2DM, and the HLA-DQB1∗0501 allele is associated with a protective effect on DN in Han ethnicity of China.
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影响因子：
158.5
作者：
Yang, Wenying;Lu, Juming;He, Jiang
通讯作者：
He, Jiang
影响因子：
19.6
作者：
So, WY;Ma, RCW;Chan, JCN
通讯作者：
Chan, JCN
影响因子：
4.5
作者：
Fernando MM;Stevens CR;Walsh EC;De Jager PL;Goyette P;Plenge RM;Vyse TJ;Rioux JD
通讯作者：
Rioux JD
影响因子：
8.2
作者：
Wu, AYT;Kong, NCT;Weir, MR
通讯作者：
Weir, MR
影响因子：
3.5
作者：
HITMAN, GA;KARIR, PK;MATHER, H
通讯作者：
MATHER, H