A tractography analysis of two deep brain stimulation white matter targets for depression.
A tractography analysis of two deep brain stimulation white matter targets for depression.
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DOI：
10.1016/j.biopsych.2008.09.021
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发表时间：
2009-02-15
影响因子：
10.6
通讯作者：
Mayberg, Helen S.
中科院分区：
文献类型：
--
作者：
Gutman, David A.;Holtzheimer, Paul E.;Behrens, Timothy E. J.;Johansen-Berg, Heidi;Mayberg, Helen S.
关键词：
胼胝体下扣带白色物质（SCCwm）或内囊前肢（ALIC）的脑深部电刺激（DBS）可能对治疗抑郁症有效。这些区域的连接模式可以告知DBS对这些靶点的作用机制。在13名非抑郁症患者中进行扩散张量成像（DTI）和概率纤维束成像，以确定SCCwm和ALIC的连接模式。为每个受试者的每个靶点生成道图，并将道体素编码为靶点唯一或共享。通过仅包括13名受试者中至少10名（>75%）受试者共有的体素来生成组水平束图。这两个目标有不同的连接模式，有重叠的区域。SCCwm显示一致的同侧连接到内侧额叶皮质，前扣带回和后扣带回的全部范围，内侧颞叶，背内侧丘脑，下丘脑，丘脑背侧核和背侧脑干。相比之下，ALIC种子表现出对额叶、内侧颞叶、小脑、丘脑、下丘脑和脑干的广泛投射。尽管通过不同的白色束，但这两个靶点的共同点是与额极、内侧颞叶、丘脑背侧核、下丘脑的连接。这两个DBS白色物质靶点的连接模式表明不同的神经网络，在涉及抑郁症和抗抑郁药反应的区域中具有重叠区域。
Deep brain stimulation (DBS) of the subcallosal cingulate white matter (SCCwm) or anterior limb of the internal capsule (ALIC) may be effective in treating depression. Connectivity patterns of these regions may inform on mechanisms of action for DBS of these targets. Diffusion tensor imaging (DTI) and probabilistic tractography were performed in 13 nondepressed subjects to determine connectivity patterns of SCCwm and ALIC. Tract maps were generated for each target in each subject, and tract voxels were coded as being unique to either target or shared. Group level tract maps were generated by including only those voxels common to at least 10 of 13 (>75%) subjects. The two targets have distinct patterns of connectivity with regions of overlap. The SCCwm showed consistent ipsilateral connections to the medial frontal cortex, the full extent of the anterior and posterior cingulate, medial temporal lobe, dorsal medial thalamus, hypothalamus, nucleus accumbens, and the dorsal brainstem. The ALIC seed, in contrast, demonstrated widespread projections to frontal pole, medial temporal lobe, cerebellum, nucleus accumbens, thalamus, hypothalamus, and brainstem. Common to both targets, albeit through distinct white matter bundles, were connections to frontal pole, medial temporal lobe, nucleus accumbens, dorsal thalamus, and hypothalamus. Connectivity patterns of these two DBS white matter targets suggest distinct neural networks with areas of overlap in regions implicated in depression and antidepressant response.
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影响因子：
7.6
作者：
Greenberg, Benjamin D.;Malone, Donald A.;Rasmussen, Steven A.
通讯作者：
Rasmussen, Steven A.
影响因子：
5.3
作者：
Croxson, PL;Johansen-Berg, H;Rushworth, MFS
通讯作者：
Rushworth, MFS
影响因子：
5.7
作者：
Heiervang, E.;Behrens, T. E. J.;Johansen-Berg, H.
通讯作者：
Johansen-Berg, H.
影响因子：
2.4
作者：
Barbas H;Saha S;Rempel-Clower N;Ghashghaei T
通讯作者：
Ghashghaei T
影响因子：
3.7
作者：
Johansen-Berg, H.;Gutman, D. A.;Mayberg, H. S.
通讯作者：
Mayberg, H. S.