Peptidoglycan synthesis in Tannerella forsythia: Scavenging is the modus operandi.
Peptidoglycan synthesis in Tannerella forsythia: Scavenging is the modus operandi.
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DOI：
10.1111/omi.12210
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发表时间：
2018-04
影响因子：
3.7
通讯作者：
Sharma A
中科院分区：
文献类型：
--
作者：
Ruscitto A;Sharma A
Tannerella pasthia是一种与牙周炎密切相关的革兰氏阴性口腔病原体。该细菌绝对需要外源N-乙酰胞壁酸（MurNAc），这是一种氨基糖，与肽聚糖骨架的氨基糖N-乙酰葡糖胺（GlcNAc）形成重复二糖单元。计算机基因组分析表明T.该菌缺乏重新合成MurNAc所需的关键生物合成酶，因此依赖于替代方法来满足其肽聚糖生物合成的要求。在龈下小生境中，细菌可以获得由同居细菌在与细胞分裂相关的细胞壁分解期间释放的MurNAc和肽聚糖片段（胞肽）。在生物膜生长过程中，嗜热链球菌还能够利用宿主唾液酸（Neu 5Ac）代替MurNAc或胞肽以使其存活。证据表明，细菌可能能够将唾液酸分流到导致肽聚糖合成的代谢途径中。本文就T.该菌能够抑制MurNAc、胞苷肽和唾液酸的肽聚糖合成，以及这些清除活性对发病机制的影响。
Tannerella forsythia is a Gram-negative oral pathogen strongly associated with periodontitis. This bacterium has an absolute requirement for exogenous Nacetylmuramic acid (MurNAc), an amino sugar which forms the repeating disaccharide unit with amino sugar N-acetylglucosamine (GlcNAc) of the peptidoglycan backbone. In silico genome analysis indicates that T. forsythia lacks the key biosynthetic enzymes needed for the de novo synthesis of MurNAc, and thus relies on alternative ways to meet its requirement for peptidoglycan biosynthesis. In the subgingival niche, the bacterium can acquire MurNAc and peptidoglycan fragments (muropeptides) released by the cohabiting bacteria during their cell wall breakdown associated with cell division.T. forsythia is able to also utilize host sialic acid (Neu5Ac) in lieu of MurNAc or muropeptides for its survival during the biofilm growth. The evidence suggests that the bacterium might be able to shunt sialic acid into a metabolic pathway leading to peptidoglycan synthesis. In this review, we explore the mechanisms by which T. forsythia is able to scavenge MurNAc, muropeptide, and sialic acid for its peptidoglycan synthesis, and the impact of these scavenging activities on pathogenesis.
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影响因子：
8
作者：
Cava, Felipe;Lam, Hubert;de Pedro, Miguel A.;Waldor, Matthew K.
通讯作者：
Waldor, Matthew K.
影响因子：
15
作者：
Espaillat, Akbar;Forsmo, Oskar;Cava, Felipe
通讯作者：
Cava, Felipe
DOI：
10.1016/0304-4165(70)90217-5
发表时间：
1970-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
AZUMA, I;THOMAS, DW;LEDERER, E
通讯作者：
LEDERER, E
影响因子：
3.7
作者：
Hajishengallis G;Lamont RJ
通讯作者：
Lamont RJ
影响因子：
4.8
作者：
Girardin, SE;Travassos, LH;Mengin-Lecreulx, D
通讯作者：
Mengin-Lecreulx, D