Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology.
Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology.
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DOI：
10.1111/j.2041-1014.2012.00663.x
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发表时间：
2012-12
影响因子：
3.7
通讯作者：
Lamont RJ
中科院分区：
文献类型：
--
作者：
Hajishengallis G;Lamont RJ
牙周研究领域的最新进展与一种新的发病机制模型相符，根据该模型，牙周炎是由一个协同且菌群失调的微生物群落引发的，而不是由某些特定的“牙周病原体”，比如“红色复合体”引发的。在这种多微生物协同作用中，群落内不同的成员或特定的基因组合发挥着不同的作用，这些作用共同塑造并稳定了一种引发疾病的微生物群。一个潜在致病群落形成的核心要求之一是某些被称为“关键病原体”的物种具有调节宿主反应的能力，这种调节会削弱免疫监视，并使平衡从内稳态转向菌群失调。关键病原体还通过与辅助病原体的交互通讯提高整个微生物群落的毒力。致病性的其他重要核心功能需要多种分子的表达（例如合适的黏附素、同源受体、蛋白水解酶和促炎表面结构/配体），这些分子共同作为群落毒力因子，为一个异质性、相容性和促炎性的微生物群落提供营养支持，从而引发一种无法消除且具有组织破坏性的宿主反应。基于这种牙周发病机制模型的基本概念，即多微生物协同作用和菌群失调，我们将其称为PSD模型。
Recent advancements in the periodontal research field are consistent with a new model of pathogenesis according to which periodontitis is initiated by a synergistic and dysbiotic microbial community rather than by select ‘periopathogens’, such as the ‘red complex’. In this polymicrobial synergy, different members or specific gene combinations within the community fulfill distinct roles that converge to shape and stabilize a disease-provoking microbiota. One of the core requirements for a potentially pathogenic community to arise involves the capacity of certain species, termed ‘keystone pathogens’, to modulate the host response in ways that impair immune surveillance and tip the balance from homeostasis to dysbiosis. Keystone pathogens also elevate the virulence of the entire microbial community through interactive communication with accessory pathogens. Other important core functions for pathogenicity require the expression of diverse molecules (e.g. appropriate adhesins, cognate receptors, proteolytic enzymes and proinflammatory surface structures/ligands), which in combination act as community virulence factors to nutritionally sustain a heterotypic, compatible and proinflammatory microbial community that elicits a non-resolving and tissue-destructive host response. On the basis of the fundamental concepts underlying this model of periodontal pathogenesis, that is, polymicrobial synergy and dysbiosis, we term it the PSD model.
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影响因子：
3.4
作者：
Coats SR;Jones JW;Do CT;Braham PH;Bainbridge BW;To TT;Goodlett DR;Ernst RK;Darveau RP
通讯作者：
Darveau RP
影响因子：
30.5
作者：
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影响因子：
3.2
作者：
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影响因子：
6.7
作者：
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通讯作者：
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影响因子：
3.1
作者：
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通讯作者：
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