VCAM1 Promotes Tumor Cell Invasion and Metastasis by Inducing EMT and Transendothelial Migration in Colorectal Cancer
VCAM1 Promotes Tumor Cell Invasion and Metastasis by Inducing EMT and Transendothelial Migration in Colorectal Cancer
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VCAM1通过诱导结直肠癌EMT和跨内皮迁移促进肿瘤细胞侵袭和转移
DOI：
10.3389/fonc.2020.01066
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发表时间：
2020-07
影响因子：
4.7
通讯作者：
Ding Yanqing
中科院分区：
文献类型：
--
作者：
Zhang Dan;Bi Jiaxin;Liang Qiaoyan;Wang Shuyang;Zhang Lingjie;Han Fangyi;Li Shengnan;Qiu Bowen;Fan Xingdi;Chen Wei;Jiao Hongli;Ye Yaping;Ding Yanqing
血管细胞粘附分子1（VCAM1）是免疫球蛋白超家族的重要成员，与乳腺癌、黑色素瘤、肾透明细胞癌等恶性肿瘤的发生发展相关。然而，VCAM1在调节结直肠癌（CRC）进展中的分子作用和机制却鲜有研究。 IHC和RT-PCR分析结果证明，与匹配的邻近正常肠上皮组织相比，VCAM1在人CRC组织中表达上调。此外，对 TCGA 和基因表达综合 (GEO) 数据库数据的分析表明，较高水平的 VCAM1 与 CRC 患者的分化差、转移和短生存期密切相关。此外，VCAM1在体外和体内显着影响CRC细胞的侵袭和转移，并激活EMT程序，使癌细胞粘附于内皮并通过形成伪足和侵袭伪足穿过血管壁。目前的研究结果表明，VCAM1 促进 CRC 肿瘤进展。
Vascular cell adhesion molecular 1 (VCAM1), an important member of the immunoglobulin superfamily, is related to the development of malignant tumors, such as breast cancer, melanoma, and renal clear cell carcinoma. However, the molecular role and mechanism of VCAM1 in the regulation of the progression of colorectal cancer (CRC) has rarely been studied. The results of IHC and RT-PCR analyses proved that VCAM1 was upregulated in human CRC tissues compared with matched adjacent normal intestinal epithelial tissues. Moreover, analysis of data from the TCGA and Gene Expression Omnibus (GEO) databases revealed that a higher level of VCAM1 was strongly correlated with poor differentiation, metastasis, and short survival in CRC patients. Furthermore, VCAM1 significantly influenced the invasion and metastasis of CRC cells in vitro and in vivo and activated the EMT program, by which cancer cells adhere to the endothelium and cross the vessel wall by forming pseudopodia and invadopodia. The current findings demonstrate that VCAM1 promotes tumor progression in CRC.
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影响因子：
15.9
作者：
Soto MS;Serres S;Anthony DC;Sibson NR
通讯作者：
Sibson NR
DOI：
10.1891/9780826121646.0002
发表时间：
2018-09
期刊：
Cancer Rehabilitation
影响因子：
--
作者：
K. Miller;R. Siegel;R. Khan;A. Jemal
通讯作者：
K. Miller;R. Siegel;R. Khan;A. Jemal
GEPIA：用于癌症和正常基因表达谱和交互式分析的网络服务器。
影响因子：
14.9
作者：
Tang Z;Li C;Kang B;Gao G;Li C;Zhang Z
通讯作者：
Zhang Z
内皮足体玫瑰花结调节肿瘤血管生成中的血管分支。
影响因子：
21.3
作者：
Seano G;Chiaverina G;Gagliardi PA;di Blasio L;Puliafito A;Bouvard C;Sessa R;Tarone G;Sorokin L;Helley D;Jain RK;Serini G;Bussolino F;Primo L
通讯作者：
Primo L
DOI：
10.1177/0184767816663138
发表时间：
2016-11
期刊：
Cahiers Élisabéthains: A Journal of English Renaissance Studies
影响因子：
--
作者：
Florence March;Nathalie Vienne-Guerrin
通讯作者：
Florence March;Nathalie Vienne-Guerrin