Chemokine signaling directs trunk lymphatic network formation along the preexisting blood vasculature.
Chemokine signaling directs trunk lymphatic network formation along the preexisting blood vasculature.
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DOI：
10.1016/j.devcel.2012.01.011
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发表时间：
2012-04-17
影响因子：
11.8
通讯作者：
Weinstein, Brant M.
中科院分区：
文献类型：
--
作者：
Cha, Young Ryun;Fujita, Misato;Butler, Matthew;Isogai, Sumio;Kochhan, Eva;Siekmann, Arndt F.;Weinstein, Brant M.
淋巴系统对体液平衡、免疫反应和许多病理过程都是至关重要的。然而，负责建立淋巴血管网络解剖形式的分子机制在很大程度上仍不清楚。在这里，我们表明，趋化因子信号提供了关键的指导线索，指导早期干淋巴网络的组装和模式。趋化因子受体Cxcr4a和Cxcr4b在淋巴管内皮细胞中表达，而趋化因子配体Cxcl12a和Cxcl12b在发育中的淋巴管排列的邻近组织中表达。斑马鱼的功能丧失和获得研究表明，趋化因子信号协调了躯干淋巴网络的逐步组装。除了为淋巴管引导机制提供证据外，这些结果还为淋巴管和血管的解剖共同排列提供了分子基础。
The lymphatic system is crucial for fluid homeostasis, immune responses, and numerous pathological processes. However, the molecular mechanisms responsible for establishing the anatomical form of the lymphatic vascular network remain largely unknown. Here, we show that chemokine signaling provides critical guidance cues directing early trunk lymphatic network assembly and patterning. The chemokine receptors Cxcr4a and Cxcr4b are expressed in lymphatic endothelium, while chemokine ligands Cxcl12a and Cxcl12b are expressed in adjacent tissues along which the developing lymphatics align. Loss- and gain- of function studies in the zebrafish demonstrate that chemokine signaling orchestrates the stepwise assembly of the trunk lymphatic network. In addition to providing evidence for a lymphatic vascular guidance mechanism, these results also suggest a molecular basis for the anatomical co-alignment of lymphatic and blood vessels.
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DOI：
10.1073/pnas.252339399
发表时间：
2002-12-10
影响因子：
11.1
作者：
David, NB;Sapède, D;Ghysen, A
通讯作者：
Ghysen, A
淋巴发育。
影响因子：
--
作者：
Butler, Matthew G.;Isogai, Sumio;Weinstein, Brant M.
通讯作者：
Weinstein, Brant M.
影响因子：
2.5
作者：
KIMMEL, CB;BALLARD, WW;SCHILLING, TF
通讯作者：
SCHILLING, TF
影响因子：
4.6
作者：
Fujita, Misato;Cha, Young R.;Weinstein, Brant M.
通讯作者：
Weinstein, Brant M.
影响因子：
--
作者：
Chong, Shang-Wei;Nguyet, Le-Minh;Jiang, Yun-Jin;Korzh, Vladimir
通讯作者：
Korzh, Vladimir