Lymphatic development.

Lymphatic development.
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淋巴发育。

DOI:
10.1002/bdrc.20155
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发表时间:
2009-09
影响因子:
--
通讯作者:
Weinstein, Brant M.
Weinstein, Brant M.
中科院分区:
生物1区
文献类型:
--
作者:
Butler, Matthew G.;Isogai, Sumio;Weinstein, Brant M.

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淋巴系统对体液平衡、免疫反应和脂肪吸收至关重要,并参与许多病理过程,包括肿瘤转移和淋巴水肿。尽管它很重要,但由于缺乏明确的分子标记,以及在体内观察淋巴细胞和对淋巴系统进行遗传和实验操作方面的困难,在了解该系统的起源和早期发展方面的进展受到阻碍。最近发现的新的分子标记,在淋巴发育中具有重要功能作用的新基因,以及研究淋巴管生成的新实验模型,已经开始对这一重要组织的出现和组装产生重要的见解。本文就胚胎发生过程中淋巴血管发育的调控机制作一综述。
The lymphatic system is essential for fluid homeostasis, immune responses, and fat absorption, and is involved in many pathological processes, including tumor metastasis and lymphedema. Despite its importance, progress in understanding the origins and early development of this system has been hampered by lack of defining molecular markers and difficulties in observing lymphatic cells in vivo and performing genetic and experimental manipulation of the lymphatic system. Recent identification of new molecular markers, new genes with important functional roles in lymphatic development, and new experimental models for studying lymphangiogenesis has begun to yield important insights into the emergence and assembly of this important tissue. This review focuses on the mechanisms regulating development of the lymphatic vasculature during embryogenesis.
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