Longevity candidate genes and their association with personality traits in the elderly.
Longevity candidate genes and their association with personality traits in the elderly.
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DOI：
10.1002/ajmg.b.32013
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发表时间：
2012-03
影响因子：
2.8
通讯作者：
Deary, Ian J.
中科院分区：
文献类型：
--
作者：
Luciano, Michelle;Lopez, Lorna M.;de Moor, Marleen H. M.;Harris, Sarah E.;Davies, Gail;Nutile, Teresa;Krueger, Robert F.;Esko, Tonu;Schlessinger, David;Toshiko, Tanaka;Derringer, Jaime L.;Realo, Anu;Hansell, Narelle K.;Pergadia, Michele L.;Pesonen, Anu-Katriina;Sanna, Serena;Terracciano, Antonio;Madden, Pamela A. F.;Penninx, Brenda;Spinhoven, Philip;Hartman, Catherina A.;Oostra, Ben A.;Janssens, A. Cecile J. W.;Eriksson, Johan G.;Starr, John M.;Cannas, Alessandra;Ferrucci, Luigi;Metspalu, Andres;Wright, Margeret J.;Heath, Andrew C.;van Duijn, Cornelia M.;Bierut, Laura J.;Raikkonen, Katri;Martin, Nicholas G.;Ciullo, Marina;Rujescu, Dan;Boomsma, Dorret I.;Deary, Ian J.
人类的寿命和性格特征都是可遗传的，并且在表型水平上一直存在联系。我们测试的假设，候选基因影响寿命较低的生物体与人类人格的五个主要方面的变化（测量的NEO-FFI和IPIP库存）加上相关的情绪状态的焦虑和抑郁。在1936年洛锡安出生队列（LBC 1936）的1000多名70岁参与者中，对6个脑表达的长寿候选基因（AFG 3L 2，FRAP 1，MAT 1A，MAT 2A，SYNJ 1和SYNJ 2）的70个单核苷酸多态性（SNP）进行了分型。在Bonferroni校正的显著性水平上，没有SNPs与人格和心理困扰特征相关（p < 0.0002），但在与宜人性和抑郁症状相关的synaptojanin-2（SYNJ 2）基因中，存在名义上显著（p < 0.05）的SNPs的过度表达。在一个非常大的复制样本的17 106名参与者进行了测试，8个SNPs，表现出名义上显着的关联在人格测量仪器。SYNJ 2中的SNP rs350292是显著的：次要等位基因与NEO宜人性量表评分平均降低0.25分相关，并且在老年队列的限制性分析中（大多数年龄> 60岁）降低0.67分。因为我们根据功能基因组学的发现选择了一组特定的长寿基因，所以有必要对其他长寿基因候选者进行进一步研究，以发现它们是否与人格和心理困扰特征相关。
Human longevity and personality traits are both heritable and are consistently linked at the phenotypic level. We test the hypothesis that candidate genes influencing longevity in lower organisms are associated with variance in the five major dimensions of human personality (measured by the NEO-FFI and IPIP inventories) plus related mood states of anxiety and depression. Seventy single nucleotide polymorphisms (SNPs) in six brain expressed, longevity candidate genes (AFG3L2, FRAP1, MAT1A, MAT2A, SYNJ1 and SYNJ2) were typed in over one thousand 70-year old participants from the Lothian Birth Cohort of 1936 (LBC1936). No SNPs were associated with the personality and psychological distress traits at a Bonferroni corrected level of significance (p < 0.0002), but there was an over-representation of nominally significant (p < 0.05) SNPs in the synaptojanin-2 (SYNJ2) gene associated with agreeableness and symptoms of depression. Eight SNPs which showed nominally significant association across personality measurement instruments were tested in an extremely large replication sample of 17 106 participants. SNP rs350292, in SYNJ2, was significant: the minor allele was associated with an average decrease in NEO agreeableness scale scores of 0.25 points, and 0.67 points in the restricted analysis of elderly cohorts (most aged > 60 years). Because we selected a specific set of longevity genes based on functional genomics findings, further research on other longevity gene candidates is warranted to discover whether they are relevant candidates for personality and psychological distress traits.
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影响因子：
4.1
作者：
Deary IJ;Gow AJ;Taylor MD;Corley J;Brett C;Wilson V;Campbell H;Whalley LJ;Visscher PM;Porteous DJ;Starr JM
通讯作者：
Starr JM
影响因子：
30.8
作者：
de Bakker, PIW;Yelensky, R;Altshuler, D
通讯作者：
Altshuler, D
影响因子：
5
作者：
Blonigen, Daniel M.;Carlson, Marie D.;Iacono, William G.
通讯作者：
Iacono, William G.
影响因子：
4.8
作者：
Nemoto, Y;Arribas, M;DeCamilli, P
通讯作者：
DeCamilli, P
影响因子：
6.3
作者：
Givens JL;Frederick M;Silverman L;Anderson S;Senville J;Silver M;Sebastiani P;Terry DF;Costa PT;Perls TT
通讯作者：
Perls TT