Obesity and related conditions and risk of inflammatory breast cancer: a nested case-control study.
Obesity and related conditions and risk of inflammatory breast cancer: a nested case-control study.
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DOI：
10.1007/s10549-020-05785-1
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发表时间：
2020-09
影响因子：
3.8
通讯作者：
Kushi LH
中科院分区：
文献类型：
--
作者：
Schairer C;Laurent CA;Moy LM;Gierach GL;Caporaso NE;Pfeiffer RM;Kushi LH
炎症性乳腺癌（IBC）是一种罕见的，知之甚少和侵袭性肿瘤。我们扩展了先前的研究结果，将高体重指数（BMI）与IBC风险大幅增加联系起来，通过在一般社区医疗保健环境中使用糖尿病、胰岛素抵抗和胆固醇代谢紊乱的病历数据，检查BMI在调整良好特征的合并症前后的相关性。我们确定了2005-2017年期间在Kaiser Permanente北方加州诊断的247例IBC病例和2470例对照，对照在出生年份和地理区域上匹配10：1，并且在诊断/索引日期之前连续入组≥13个月。我们评估了诊断/索引日期前6年至1年的暴露情况，使用逻辑回归计算比值比（OR）和95%置信区间（CI）。校正合并症前，BMI 25-<30、30-<35和≥ 35与<25 kg/m2相比的OR（95% CI）分别为1.5（0.9-2.3）、2.0（1.2-3.1）和2.5（1.4-4.4）。校正糖尿病前期/糖尿病、HDL-C和甘油三酯水平以及血脂异常后，相应的OR分别为1.3（0.8-2.1）、1.6（0.9-2.9）和1.9（1.0-3.5）。在校正模型中，HDL-C水平<50 mg/dL与≥65 mg/dL相比的OR为2.0（1.2-3.3）。在另一个模型中，调整BMI、糖尿病前期/糖尿病和血脂异常后，甘油三酯/HDL-C比值≥2.50与<1.62的OR为1.7（1.1-2.8）。结果没有显着差异雌激素受体状态。肥胖和胰岛素抵抗的措施独立增加IBC的风险，肥胖和低HDL-C水平。这些发现如果得到证实，将对IBC的预防产生影响。
Inflammatory breast cancer (IBC) is a rare, poorly understood and aggressive tumor. We extended prior findings linking high body mass index (BMI) to substantial increased IBC risk by examining BMI associations before and after adjustment for well-characterized comorbidities using medical record data for diabetes, insulin resistance, and disturbances of cholesterol metabolism in a general community healthcare setting. We identified 247 incident IBC cases diagnosed at Kaiser Permanente Northern California between 2005–2017 and 2470 controls matched 10:1 on birth year and geographic area and with ≥13 months of continuous enrollment prior to diagnosis/index date. We assessed exposures from 6 years up to one year prior to the diagnosis/index date, using logistic regression to calculate odds ratios (ORs) with 95% confidence intervals (CIs). Before adjustment for comorbidities, ORs (95% CIs) for BMI of 25-<30, 30-<35, and ≥ 35 compared to <25 kg/m2 were 1.5 (0.9–2.3), 2.0 (1.2–3.1), and 2.5 (1.4–4.4), respectively. After adjustment for pre-diabetes/diabetes, HDL-C and triglyceride levels, and dyslipidemia, corresponding ORs were 1.3 (0.8–2.1), 1.6 (0.9–2.9), and 1.9 (1.0–3.5). The OR for HDL-C levels <50 mg/dL compared to ≥65 mg/dL was 2.0 (1.2–3.3) in the adjusted model. In a separate model the OR for a triglyceride/HDL-C ratio ≥2.50 compared to <1.62 was 1.7 (1.1–2.8) after adjustment for BMI, pre-diabetes/diabetes, and dyslipidemia. Results did not differ significantly by estrogen receptor status. Obesity and measures of insulin resistance independently increased IBC risk as did obesity and low HDL-C levels. These findings, if confirmed, have implications for IBC prevention.
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影响因子：
16.2
作者：
Bullard KM;Saydah SH;Imperatore G;Cowie CC;Gregg EW;Geiss LS;Cheng YJ;Rolka DB;Williams DE;Caspersen CJ
通讯作者：
Caspersen CJ
影响因子：
10.3
作者：
Hance, KW;Anderson, WF;Levine, PH
通讯作者：
Levine, PH
影响因子：
5.6
作者：
Koebnick, Corinna;Smith, Ning;Kushi, Lawrence H.
通讯作者：
Kushi, Lawrence H.
影响因子：
5.5
作者：
Nichols GA;Desai J;Elston Lafata J;Lawrence JM;O'Connor PJ;Pathak RD;Raebel MA;Reid RJ;Selby JV;Silverman BG;Steiner JF;Stewart WF;Vupputuri S;Waitzfelder B;SUPREME-DM Study Group
通讯作者：
SUPREME-DM Study Group
影响因子：
11.5
作者：
Hostalek U;Gwilt M;Hildemann S
通讯作者：
Hildemann S