A genetic mosaic screen identifies genes modulating Notch signaling in Drosophila.
A genetic mosaic screen identifies genes modulating Notch signaling in Drosophila.
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基因镶嵌筛选鉴定了果蝇中调节 Notch 信号传导的基因。
DOI：
10.1371/journal.pone.0203781
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Ren L;Mo D;Li Y;Liu T;Yin H;Jiang N;Zhang J
Notch信号在大多数多细胞生物中是保守的，在动物发育过程中起着关键作用。Notch信号的核心成分和主要信号转导机制已被广泛研究。然而，我们对Notch信号活性在不同发育过程中如何调节的理解仍然不完整。在这里，我们报告了一个遗传镶嵌屏幕在果蝇，导致识别Notch信号调节器在翅膀发育。我们发现了一组形成苍蝇翅膀边缘所需的基因，这是一个严格依赖于平衡Notch信号活性的发育过程。这些基因编码转录因子、蛋白磷酸酶、液泡ATP酶和RNA转运、稳定性和翻译所需的因子。我们的数据支持Notch信号通过广泛的分子过程控制的观点。这些结果也为进一步研究Me31B和Wdr62作为Notch信号活性的两种新型调节剂提供了基础。
Notch signaling is conserved in most multicellular organisms and plays critical roles during animal development. The core components and major signal transduction mechanism of Notch signaling have been extensively studied. However, our understanding of how Notch signaling activity is regulated in diverse developmental processes still remains incomplete. Here, we report a genetic mosaic screen in Drosophila melanogaster that leads to identification of Notch signali ng modulators during wing development. We discovered a group of genes required for the formation of the fly wing margin, a developmental process that is strictly dependent on the balanced Notch signaling activity. These genes encode transcription factors, protein phosphatases, vacuolar ATPases and factors required for RNA transport, stability, and translation. Our data support the view that Notch signaling is controlled through a wide range of molecular processes. These results also provide foundations for further study by showing that Me31B and Wdr62 function as two novel modulators of Notch signaling activity.
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DOI：
10.1534/g3.116.028951
发表时间：
2016-08-09
期刊：
G3 (Bethesda, Md.)
影响因子：
--
作者：
Ables ET;Hwang GH;Finger DS;Hinnant TD;Drummond-Barbosa D
通讯作者：
Drummond-Barbosa D
影响因子：
16.2
作者：
Barbee, Scott A.;Estes, Patricia S.;Ramaswami, Mani
通讯作者：
Ramaswami, Mani
影响因子：
4.6
作者：
Jauffred, Bertrand;Llense, Flora;Bellaiche, Yohanns
通讯作者：
Bellaiche, Yohanns
影响因子：
4.6
作者：
Jia D;Soylemez M;Calvin G;Bornmann R;Bryant J;Hanna C;Huang YC;Deng WM
通讯作者：
Deng WM
影响因子：
11.4
作者：
Hermle, Tobias;Guida, Maria Clara;Simons, Matias
通讯作者：
Simons, Matias