Non-IgE-mediated food hypersensitivity.
Non-IgE-mediated food hypersensitivity.
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DOI：
10.1186/s13223-018-0285-2
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Kim H
中科院分区：
文献类型：
--
作者：
Connors L;O'Keefe A;Rosenfield L;Kim H
非免疫球蛋白E（IgE）介导的食物超敏反应包括一系列主要影响胃肠道的疾病。本文将重点介绍以下常见的非IgE介导的食物过敏综合征：食物蛋白诱导的小肠结肠炎综合征（FPIES），过敏性直肠结肠炎（AP），食物蛋白诱导的肠病（FPE）和乳糜泻。FPIES，AP和FPE通常出现在婴儿期，最常见的是由牛奶蛋白或大豆引发。常见的表现特征是FPIES的大量呕吐和脱水; AP的血便和粘液便; FPE的长期腹泻伴吸收不良。由于大多数这些疾病没有确诊的非侵入性诊断测试，诊断是基于令人信服的病史和症状的解决与食物避免。FPIES、AP和FPE的主要管理措施是避免疑似刺激性食物，定期进行口服食物挑战以评估解决方案，这通常发生在生命的最初几年。乳糜泻是一种由麸质摄入引起的免疫介导的损伤，导致遗传易感个体的小肠绒毛萎缩。需要血清学检查和小肠活检来确诊乳糜泻，治疗需要终身坚持严格的无麸质饮食。
Non-immunoglobulin E (IgE)-mediated food hypersensitivity includes a spectrum of disorders that predominantly affect the gastrointestinal tract. This review will focus on the following more common non-IgE-mediated food hypersensitivity syndromes: food protein-induced enterocolitis syndrome (FPIES), allergic proctocolitis (AP), food protein-induced enteropathy (FPE) and celiac disease. FPIES, AP and FPE typically present in infancy and are most commonly triggered by cow’s milk protein or soy. The usual presenting features are profuse emesis and dehydration in FPIES; blood-streaked and mucousy stools in AP; and protracted diarrhea with malabsorption in FPE. Since there are no confirmatory noninvasive diagnostic tests for most of these disorders, the diagnosis is based on a convincing history and resolution of symptoms with food avoidance. The mainstay of management for FPIES, AP and FPE is avoidance of the suspected inciting food, with periodic oral food challenges to assess for resolution, which generally occurs in the first few years of life. Celiac disease is an immune-mediated injury caused by the ingestion of gluten that leads to villous atrophy in the small intestine in genetically susceptible individuals. Serologic tests and small intestinal biopsy are required to confirm the diagnosis of celiac disease, and management requires life-long adherence to a strict gluten-free diet.
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影响因子：
8
作者：
Mehr, Sam;Kakakios, Alyson;Kemp, Andrew S.
通讯作者：
Kemp, Andrew S.
DOI：
10.1016/j.giec.2012.07.003
发表时间：
2012-10-01
影响因子：
--
作者：
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通讯作者：
Jabri, Bana
影响因子：
9.8
作者：
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通讯作者：
Murray, Joseph A.
影响因子：
5.1
作者：
LAKE, AM;WHITINGTON, PF;HAMILTON, SR
通讯作者：
HAMILTON, SR
影响因子：
14.2
作者：
Sampson, Hugh A.;Aceves, Seema;Wood, Robert
通讯作者：
Wood, Robert