Evidence for overwintering and autochthonous transmission of Usutu virus to wild birds following its redetection in the United Kingdom.
Evidence for overwintering and autochthonous transmission of Usutu virus to wild birds following its redetection in the United Kingdom.
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DOI：
10.1111/tbed.14738
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发表时间：
2022-11
影响因子：
4.3
通讯作者：
Johnson, Nicholas
中科院分区：
文献类型：
--
作者：
Folly, Arran J.;Sewgobind, Sanam;Hernandez-Triana, Luis M.;Mansfield, Karen L.;Lean, Fabian Z. X.;Lawson, Becki;Seilern-Moy, Katharina;Cunningham, Andrew A.;Spiro, Simon;Wrigglesworth, Ethan;Pearce-Kelly, Paul;Herdman, Trent;Johnston, Colin;Berrell, Morgan;Vaux, Alexander G. C.;Medlock, Jolyon M.;Johnson, Nicholas
关键词：
Usutu病毒(USUV)是欧洲新出现的一种人畜共患虫媒病毒，主要感染欧亚黑鸟(Turdus Merula)。蚊媒病毒要在温带地区持续存在，必须通过媒介传播，或者在寄主或滞育媒介中越冬，以促进原地传播。我们在2021年对宿主和病媒进行了监测，以澄清USUV在2020年首次在英国越冬后是否在那里越冬。从175只死鸟提交的材料中，我们在一只黑鸟身上检测到1例USUV感染，并从中获得了USUV的完整基因组。使用分子时钟分析，我们证明了2021年的探测与2020年英国大伦敦，USUV序列有一个最近的共同祖先。此外，我们在指标点的圈养鸟类的86份血清样本中发现了10份USUV特异性中和抗体，证明了原位隐蔽感染和潜在的持续传播。然而，从4966只蚊子中，我们没有检测到USUV RNA，这表明在采样期间媒介群落中的流行率没有或很低。总而言之，这些结果表明USUV在英国越冬，从而为这种媒介传播的病毒疾病继续向北扩展提供了经验证据。目前，我们的检测表明病毒的持久性受到地理限制。随着时间的推移，将需要进一步的检测来证明长期的建立。目前尚不清楚英国以及其他高纬度地区是否能够支持地方性USUV感染。
Usutu virus (USUV) is an emerging zoonotic arbovirus in Europe, where it primarily impacts Eurasian blackbirds (Turdus merula). For mosquito‐borne viruses to persist in temperate areas, transovarial transmission in vectors or overwintering in either hosts or diapausing vectors must occur to facilitate autochthonous transmission. We undertook surveillance of hosts and vectors in 2021 to elucidate whether USUV had overwintered in the United Kingdom (UK) following its initial detection there in 2020. From 175 dead bird submissions, we detected 1 case of USUV infection, in a blackbird, from which a full USUV genome was derived. Using a molecular clock analysis, we demonstrate that the 2021 detection shared a most recent common ancestor with the 2020 Greater London, UK, USUV sequence. In addition, we identified USUV‐specific neutralizing antibodies in 10 out of 86 serum samples taken from captive birds at the index site, demonstrating in situ cryptic infection and potential sustained transmission. However, from 4966 mosquitoes, we detected no USUV RNA suggesting that prevalence in the vector community was absent or low during sampling. Combined, these results suggest that USUV overwintered in the UK, thus providing empirical evidence for the continued northward expansion of this vector‐borne viral disease. Currently, our detection indicates geographically restricted virus persistence. Further detections over time will be required to demonstrate long‐term establishment. It remains unclear whether the UK, and by extension other high‐latitude regions, can support endemic USUV infection.
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DOI：
10.2807/1560-7917.es.2020.25.41.2001732
发表时间：
2020-10
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Folly AJ;Lawson B;Lean FZ;McCracken F;Spiro S;John SK;Heaver JP;Seilern-Moy K;Masters N;Hernández-Triana LM;Phipps LP;Nuñez A;Fooks AR;Cunningham AA;Johnson N;McElhinney LM
通讯作者：
McElhinney LM
欧洲和非洲的新兴arbovirus忽视了USUTU病毒的进化史和扩散的重建。
影响因子：
6.4
作者：
Engel D;Jöst H;Wink M;Börstler J;Bosch S;Garigliany MM;Jöst A;Czajka C;Lühken R;Ziegler U;Groschup MH;Pfeffer M;Becker N;Cadar D;Schmidt-Chanasit J
通讯作者：
Schmidt-Chanasit J
影响因子：
158.5
作者：
Nash, D;Mostashari, F;Smith, P
通讯作者：
Smith, P
影响因子：
19
作者：
Cadar, D.;Luehken, R.;Schmidt-Chanasit, J.
通讯作者：
Schmidt-Chanasit, J.
影响因子：
4.3
作者：
Manore, C. A.;Beechler, B. R.
通讯作者：
Beechler, B. R.