Selective Attention Controls Olfactory Decisions and the Neural Encoding of Odors.
Selective Attention Controls Olfactory Decisions and the Neural Encoding of Odors.
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DOI：
10.1016/j.cub.2018.05.011
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发表时间：
2018-07-23
期刊：
影响因子：
--
通讯作者：
Wesson DW
中科院分区：
文献类型：
--
作者：
Carlson KS;Gadziola MA;Dauster ES;Wesson DW
关键的动物行为，特别是啮齿动物的关键行为，是以非常协调的方式由气味引导的，然而许多额外的感觉线索在这些生态环境中竞争认知资源。啮齿动物可以进行这种气味引导行为，这表明它们可以选择性地注意气味。事实上，更高级的认知过程，如学习和记忆、决策和行动选择，依赖于基于它们的相对突出度对感觉线索的适当过滤。我们开发了一种行为范式，以揭示大鼠能够在竞争的情态外刺激存在的情况下选择性地注意气味。我们发现，这种选择性的注意力有助于做出准确的气味引导决定，而随着经验的增加，这种决定会变得更加强大。此外，我们发现，对气味的选择性注意适应性地增强了它们在嗅结节神经元中的表现，嗅结节是腹侧纹状体的一个嗅觉皮质区域，被认为是在动机行为背景下评估感觉信息的组成部分。气味导向的选择性注意在气味预期增强的时刻施加影响，并通过在信噪比类型编码方案中增加刺激对比度来增强气味表征。综上所述，这些结果表明，大鼠通过选择性注意来优化嗅觉结果。此外，我们在嗅结节中发现的注意力相关编码挑战了丘脑中继器对于注意控制感觉编码是不可或缺的概念。
Critical animal behaviors, especially among rodents, are guided by odors in remarkably well-coordinated manners, yet many extramodal sensory cues compete for cognitive resources in these ecological contexts. That rodents can engage in such odor-guided behaviors suggests that they can selectively attend to odors. Indeed, higher order cognitive processes, such as learning and memory, decision making and action selection, rely on the proper filtering of sensory cues based on their relative salience. We developed a behavioral paradigm to reveal that rats are capable of selectively attending to odors in the presence of competing extramodal stimuli. We found that this selective attention facilitates accurate odor-guided decisions, which become further strengthened with experience. Further, we uncovered that selective attention to odors adaptively sharpens their representation among neurons in the olfactory tubercle, an olfactory cortex region of the ventral striatum considered integral for evaluating sensory information in the context of motivated behaviors. Odor-directed selective attention exerts influences during moments of heightened odor anticipation and enhances odorant representation by increasing stimulus contrast in a signal-to-noise type coding scheme. Together, these results reveal that rats engage selective attention to optimize olfactory outcomes. Further, our finding of attention-dependent coding in the olfactory tubercle challenges the notion that a thalamic relay is integral for the attentional control of sensory coding.
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影响因子：
1.9
作者：
Berridge KC;Aldridge JW
通讯作者：
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影响因子：
3.7
作者：
Hirokawa J;Sadakane O;Sakata S;Bosch M;Sakurai Y;Yamamori T
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神经元型特异性信号，用于腹侧对段区域的奖励和惩罚。
影响因子：
64.8
作者：
Cohen, Jeremiah Y.;Haesler, Sebastian;Vong, Linh;Lowell, Bradford B.;Uchida, Naoshige
通讯作者：
Uchida, Naoshige
影响因子：
56.9
作者：
HUBEL, DH;HENSON, CO;GALAMBOS, R
通讯作者：
GALAMBOS, R