Understanding human original actions directed at real-world goals: the role of the lateral prefrontal cortex.
Understanding human original actions directed at real-world goals: the role of the lateral prefrontal cortex.
复制标题
了解针对现实世界目标的人类原始动作：前额叶皮层的作用。
DOI：
10.1016/j.neuroimage.2014.09.012
复制
发表时间：
2014-12
期刊：
影响因子：
5.7
通讯作者：
West WC
中科院分区：
文献类型：
--
作者：
Sitnikova T;Rosen BR;Lord LD;West WC
适应性、原创性的行动可以在多种情境下取得成功，需要了解与目标相关的内容。识别相关内容也可能有助于预测观察到的原始动作的运动学。在动作观察过程中，感官输入和预期动作运动学之间的比较被认为对于准确的目标推断至关重要。在人类和非人类灵长类动物中进行的实验室任务实验研究表明，外侧前额叶皮层 (LPFC) 可以学习、分层组织和使用与目标相关的信息。为了确定这种 LPFC 能力是否可以推广到现实世界的认知，我们在理解嵌入在现实生活行为的视频描述中的原始和常见的目标导向动作时，记录了人脑中的功能磁共振成像 (fMRI) 数据。我们假设 LPFC 将有助于形成原始动作的运动学预测所需的目标相关表示。此外，还采用静息态功能磁共振成像来检查视频功能磁共振成像实验中描绘的大脑区域之间的功能连接。根据行为数据，可以通过在不同抽象级别识别与现实生活目标相关的元素来理解原始视频。相对于通常的视频场景，左侧 LPFC 的四个区域的活动增强模式与之前关于表示与实验室目标相关的抽象和具体刺激维度的神经影像学发现一致。在左前部 LPFC 中，当能够实现感知的总体行为目标的大类物体和动作的表示可能会偏差原始动作的运动学预测时，活动选择性地增加。相反，在更靠后的区域，即使目标物体的具体属性更有可能使运动学预测产生偏差，活动也会增加。在沿头尾 LPFC 轴的连续区域之间观察到功能连接，但在不直接相邻的区域之间观察不到功能连接。这些发现将 LPFC 功能的代表性层次结构概括为不同的核心原则，这些原则可以管理灵活的现实生活行为的产生和理解。
Adaptive, original actions, which can succeed in multiple contextual situations, require understanding of what is relevant to a goal. Recognizing what is relevant may also help in predicting kinematics of observed, original actions. During action observation, comparisons between sensory input and expected action kinematics have been argued critical to accurate goal inference. Experimental studies with laboratory tasks, both in humans and nonhuman primates, demonstrated that the lateral prefrontal cortex (LPFC) can learn, hierarchically organize, and use goal-relevant information. To determine whether this LPFC capacity is generalizable to real-world cognition, we recorded functional magnetic resonance imaging (fMRI) data in the human brain during comprehension of original and usual object-directed actions embedded in video-depictions of real-life behaviors. We hypothesized that LPFC will contribute to forming goal-relevant representations necessary for kinematic predictions of original actions. Additionally, resting-state fMRI was employed to examine functional connectivity between the brain regions delineated in the video fMRI experiment. According to behavioral data, original videos could be understood by identifying elements relevant to real-life goals at different levels of abstraction. Patterns of enhanced activity in four regions in the left LPFC, evoked by original, relative to usual, video scenes, were consistent with previous neuroimaging findings on representing abstract and concrete stimuli dimensions relevant to laboratory goals. In the anterior left LPFC, the activity increased selectively when representations of broad classes of objects and actions, which could achieve the perceived overall behavioral goal, were likely to bias kinematic predictions of original actions. In contrast, in the more posterior regions, the activity increased even when concrete properties of the target object were more likely to bias the kinematic prediction. Functional connectivity was observed between contiguous regions along the rostro-caudal LPFC axis, but not between the regions that were not immediately adjacent. These findings generalize the representational hierarchy account of LPFC function to diverse core principles that can govern both production and comprehension of flexible real-life behavior.
登录
查看更多内容
DOI：
10.1093/cercor/bhq026
发表时间：
2010-12
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Bach P;Peelen MV;Tipper SP
通讯作者：
Tipper SP
DOI：
10.1073/pnas.1220826110
发表时间：
2013-07-09
影响因子：
11.1
作者：
Crossley, Nicolas A.;Mechelli, Andrea;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.
影响因子：
2.5
作者：
Freedman, DJ;Riesenhuber, M;Miller, EK
通讯作者：
Miller, EK
影响因子：
2.9
作者：
Cole MW;Etzel JA;Zacks JM;Schneider W;Braver TS
通讯作者：
Braver TS
影响因子：
4.3
作者：
Glenberg, AM;Robertson, DA
通讯作者：
Robertson, DA