Itch signaling in the nervous system.
Itch signaling in the nervous system.
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DOI：
10.1152/physiol.00007.2011
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发表时间：
2011-08
期刊：
影响因子：
--
通讯作者：
Chen ZF
中科院分区：
文献类型：
--
作者：
Jeffry J;Kim S;Chen ZF
瘙痒是一种主要的躯体感觉，沿着疼痛、温度和触觉，由躯体感觉系统检测和传递。瘙痒可以是一种急性感觉，与蚊子叮咬有关，也可以是一种慢性疾病，如特应性皮炎。刺激的起源可以位于外周或全身，并与器官衰竭或癌症有关。瘙痒也是一种源自大脑的感知。瘙痒被广泛地表征为组胺依赖性（组胺能）或组胺非依赖性（非组胺能），这两者都通过C纤维亚群以及啮齿动物脊髓中表达胃泌素释放肽受体（GRPR）的二级神经元和脊髓丘脑轨道（STT）神经元来中继。从历史上看，瘙痒研究主要限于临床和心理物理学研究，以及组胺介导的机制。相反，尽管大多数慢性瘙痒是由非组胺能机制介导的，但对非组胺能瘙痒的信号传导机制却知之甚少。在过去的几年中，在理解瘙痒的分子信号传导方面取得了重要进展，这主要归功于小鼠遗传学的引入。本文就近年来啮齿类动物瘙痒感觉的分子机制作一综述。
Itch is a major somatic sensation, along with pain, temperature and touch, detected and relayed by the somatosensory system. Itch can be an acute sensation, associated with mosquito bite, or a chronic condition, like atopic dermatitis. The origins of the stimulus can be localized in the periphery or systemic, and associated with organ failure or cancer. Itch is also a perception originating in the brain. Itch is broadly characterized as either histamine-dependent (histaminergic) or histamine-independent (nonhistaminergic), both of which are relayed by subsets of C-fibers, and by the second-order neurons expressing gastrin-releasing peptide receptor (GRPR) and spinothalamic track (STT) neurons in the spinal cord of rodents. Historically, itch research has been primarily limited to clinical and psychophysical studies, and to histamine-mediated mechanisms. In contrast, little is known about signaling mechanisms underlying nonhistaminergic itch, despite the fact that the majority of chronic itch are mediated by nonhistaminergic mechanisms. During the past few years, important progress has been made in understanding of molecular signaling of itch, largely due to the introduction of mouse genetics. In this review, we examine some of molecular mechanisms underlying itch sensation with an emphasis on recent studies in rodents.
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作者：
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DOI：
10.1073/pnas.1011221107
发表时间：
2010-09-07
影响因子：
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