External induction and stabilization of brain oscillations in the human.
External induction and stabilization of brain oscillations in the human.
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DOI：
10.1016/j.brs.2021.03.011
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发表时间：
2021-05
影响因子：
7.7
通讯作者：
Jamil A
中科院分区：
文献类型：
--
作者：
Hosseinian T;Yavari F;Biagi MC;Kuo MF;Ruffini G;Nitsche MA;Jamil A
Neural oscillations in the cerebral cortex are associated with a range of cognitive processes and neuropsychiatric disorders. However, non-invasively modulating oscillatory activity remains technically challenging, due to limited strength, duration, or non-synchronization of stimulation waveforms with endogenous rhythms. We hypothesized that applying controllable phase-synchronized repetitive transcranial magnetic stimulation pulses (rTMS) with alternating currents (tACS) may induce and stabilize neuro-oscillatory resting-state activity at targeted frequencies. Using a novel circuit to precisely synchronize rTMS pulses with phase of tACS, we empirically tested whether combined, 10-Hz prefrontal bilateral stimulation could induce and stabilize 10-Hz oscillations in the bilateral prefrontal cortex (PFC). 25 healthy participants took part in a repeated-measures design. Whole-brain resting-state EEG in eyes-open (EO) and eyes-closed (EC) was recorded before (baseline), immediately (1-min), and 15- and 30-min after stimulation. Bilateral, phase-synchronized rTMS aligned to the positive tACS peak was compared with rTMS at tACS trough, with bilateral tACS or rTMS on its own, and to sham. 10-Hz resting-state PFC power increased significantly with peak-synchronized rTMS + tACS (EO: 44.64%, EC: 46.30%, p < 0.05) compared to each stimulation protocol on its own, and sham, with effects spanning between prefrontal and parietal regions and sustaining throughout 30-min. No effects were observed with the sham protocol. Moreover, rTMS timed to the negative tACS trough did not induce local or global changes in oscillations. Phase-synchronizing rTMS with tACS may be a viable approach for inducing and stabilizing neuro-oscillatory activity, particularly in scenarios where endogenous oscillatory tone is attenuated, such as disorders of consciousness or major depression. Non-invasively inducing and stabilizing neural oscillations remains challenging. We develop a controllable phase-synchronized circuit to combine rTMS and tACS. This circuit was tested for inducing 10 Hz oscillations in healthy prefrontal cortex. 10 Hz rTMS synchronized to the positive 10 Hz tACS peak induced stable after-effects. Phase-synchronized stimulation is a viable approach for oscillatory neuromodulation.
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DOI：
10.1016/j.clinph.2009.08.016
发表时间：
2009-12
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Rossi S;Hallett M;Rossini PM;Pascual-Leone A;Safety of TMS Consensus Group
通讯作者：
Safety of TMS Consensus Group
影响因子：
5.7
作者：
Neuling T;Ruhnau P;Fuscà M;Demarchi G;Herrmann CS;Weisz N
通讯作者：
Weisz N
神经元网络在驱动人类运动皮层可塑性中的作用
影响因子：
3.7
作者：
Hamada, Masashi;Murase, Nagako;Rothwelll, John C.
通讯作者：
Rothwelll, John C.
意识障碍静息态脑电图分析综述
影响因子：
3.4
作者：
Bai Y;Xia X;Li X
通讯作者：
Li X
影响因子：
3.1
作者：
Antal A;Herrmann CS
通讯作者：
Herrmann CS