Multinuclear absolute magnetic resonance thermometry

Multinuclear absolute magnetic resonance thermometry
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多核绝对磁共振测温

DOI:
10.1038/s42005-019-0252-3
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发表时间:
2019
影响因子:
5.5
通讯作者:
Alon, Leeor
Alon, Leeor
中科院分区:
物理与天体物理1区
文献类型:
--
作者:
Silletta, Emilia V.;Jerschow, Alexej;Madelin, Guillaume;Alon, Leeor

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绝对温度的非侵入性测量对于正确表征各种病理和评估介入手术期间的热剂量非常重要。质子(氢核)磁共振(MR)频移方法可用于绘制相对温度变化。然而,在主磁场的时空变化和缺乏本地内部频率参考的挑战,绝对温度的测定。在这里,我们介绍了一个多核的方法,绝对MR测温的基础上,氢和钠核表现出独特的和独特的特征频率依赖于温度和电解质浓度的事实。证明了两个核的进动频率差与绝对温度之间的一一对应关系。在具有不同NaCl浓度的水溶液中、在琼脂糖凝胶样品中和在新鲜切除的离体小鼠组织中进行概念验证实验。一维化学位移成像实验也表现出良好的协议与红外测量。
Non-invasive measurement of absolute temperature is important for proper characterization of various pathologies and for evaluation of thermal dose during interventional procedures. The proton (hydrogen nucleus) magnetic resonance (MR) frequency shift method can be used to map relative temperature changes. However, spatiotemporal variations in the main magnetic field and the lack of local internal frequency reference challenge the determination of absolute temperature. Here, we introduce a multinuclear method for absolute MR thermometry, based on the fact that the hydrogen and sodium nuclei exhibit a unique and distinct characteristic frequency dependence with temperature and with electrolyte concentration. A one-to-one mapping between the precession frequency difference of the two nuclei and absolute temperature is demonstrated. Proof-of-concept experiments were conducted in aqueous solutions with different NaCl concentrations, in agarose gel samples, and in freshly excised ex vivo mouse tissues. One-dimensional chemical shift imaging experiments also demonstrated excellent agreement with infrared measurements.
DOI: 10.1002/mrm.22206
发表时间: 2010-02
影响因子: 3.3
作者:
Holbrook, Andrew B.;Santos, Juan M.;Kaye, Elena;Rieke, Viola;Pauly, Kim Butts
通讯作者: Pauly, Kim Butts
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DOI: 10.1063/1.1742886
发表时间: 1956
影响因子: 4.4
作者:
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DOI: --
发表时间: 1968
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DOI: 10.1016/j.ejmp.2009.11.006
发表时间: 2010-10-01
期刊: PHYSICA MEDICA
影响因子: --
作者:
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