Real-time MR thermometry for monitoring HIFU ablations of the liver.
Real-time MR thermometry for monitoring HIFU ablations of the liver.
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DOI：
10.1002/mrm.22206
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发表时间：
2010-02
影响因子：
3.3
通讯作者：
Pauly, Kim Butts
中科院分区：
文献类型：
--
作者：
Holbrook, Andrew B.;Santos, Juan M.;Kaye, Elena;Rieke, Viola;Pauly, Kim Butts
关键词：
高分辨率和高速脉冲序列提出了监测高强度聚焦超声（HIFU）消融的肝脏在运动的存在。该序列利用多项式阶相位饱和带进行外部体积抑制，然后是空间光谱激发和三个读出分段EPI交织。图像用无参考测温法处理，每帧生成温升图像。在RTHawk中进行序列和重建，并用于在聚丙烯酰胺凝胶体（62.4声W， 50秒，550 kHz）中对静止和运动声波进行成像。对运动和静止实验的温升图像进行了比较。发热点与相应的温升曲线吻合较好。静止声波的温度标准偏差为0.15°C，而两种不同速度的手动移动声波的温度标准偏差分别为0.28°C和0.43°C。尽管磁化率发生了变化，但相对于换能器移动模体（在不加热的情况下）不会导致错误的温度升高。该系统在5名正常志愿者的未加热肝脏上进行了测试。平均温升为- 0.05℃，标准差为1.48℃。这种标准偏差对于监测HIFU消融是可以接受的，这表明实时成像的移动HIFU超声在临床上是可能的。
A high resolution and high speed pulse sequence is presented for monitoring high intensity focused ultrasound (HIFU) ablations in the liver in the presence of motion. The sequence utilizes polynomial-order phase saturation bands to perform outer volume suppression, followed by spatial-spectral excitation and three readout segmented EPI interleaves. Images are processed with referenceless thermometry to create temperature rise images every frame. The sequence and reconstruction were implemented in RTHawk and used to image stationary and moving sonications in a polyacrylamide gel phantom (62.4 acoustic W, 50 sec, 550 kHz). Temperature rise images were compared between moving and stationary experiments. Heating spots and corresponding temperature rise plots matched very well. The stationary sonication had a temperature standard deviation of 0.15°C, compared to values of 0.28°C and 0.43°C measured for two manually-moved sonications at different velocities. Moving the phantom (while not heating) with respect to the transducer did not cause false temperature rises, despite susceptibility changes. The system was tested on non-heated livers of 5 normal volunteers. The mean temperature rise was −0.05°C with a standard deviation of 1.48°C. This standard deviation is acceptable for monitoring HIFU ablations, suggesting real time imaging of moving HIFU sonications can be clinically possible.
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