In vivo and in vitro comparison of female and male nociceptors.
In vivo and in vitro comparison of female and male nociceptors.
复制标题
体内和男性伤害感受器的体外比较。
DOI：
10.1016/j.jpain.2012.09.009
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发表时间：
2012-12
期刊：
影响因子：
4
通讯作者：
Levine, Jon D.
中科院分区：
文献类型：
--
作者：
Hendrich, Jan;Alvarez, Pedro;Joseph, Elizabeth K.;Ferrari, Luiz F.;Chen, Xiaojie;Levine, Jon D.
虽然人们普遍认为女性对各种形式的伤害性刺激具有较低的疼痛阈值，但伤害性疼痛中这种性别二态性的机制基础仍有待阐明。我们证实，在大鼠中，雌性具有较低的皮肤机械伤害感受阈值，并在肌肉中建立了类似的性别二态性。为了确定疼痛阈值性别二态性是否存在外周机制，我们比较了培养的雌性和雄性大鼠腓肠肌的 DRG 神经元的生物物理特性。雌性大鼠的 DRG 神经元支配腓肠肌，具有更加超极化的静息膜电位。为了确定这是否与较高的机械伤害性阈值相关，与我们的工作假设相反，我们比较了雄性和雌性大鼠体内支配腓肠肌的伤害性传入的功能。雌性大鼠肌肉中的 C 纤维伤害感受器比雄性大鼠具有更高的机械阈值。这些伤害感受器的其他反应特征没有显着差异。因此，体外和体内电生理学实验都支持这样的观点，即女性较低的机械伤害性阈值可能是由于中枢神经系统机制中的性别二态性所致，这种差异足以克服外周疼痛机制中的相反差异。
While it is generally accepted that women have lower pain thresholds for diverse forms of noxious stimuli, the mechanistic basis for this sexual dimorphism in nociceptive pain remains to be elucidated. We confirm, in the rat, that females have lower cutaneous mechanical nociceptive thresholds, and establish a similar sexual dimorphism in muscle. To determine if a peripheral mechanism underlies this sexual dimorphism in pain threshold, we compared biophysical properties of cultured DRG neurons that innervated the gastrocnemius muscle in female and male rats. DRG neurons from female rats, which innervated the gastrocnemius muscle, had a more hyperpolarized resting membrane potential. To determine if this was associated with a higher mechanical nociceptive threshold, opposite to our working hypothesis, we compared the function, in vivo, of nociceptive afferents innervating the gastrocnemius muscle in male and female rats. C-fiber nociceptors innervating muscle in female rats had higher mechanical thresholds than those in males. Other response characteristics of these nociceptors were not significantly different. Thus, both in vitro and in vivo electrophysiology experiments support the idea that lower mechanical nociceptive threshold in females may be due to sexual dimorphism in CNS mechanisms, a difference large enough to overcome an opposing difference in peripheral pain mechanisms.
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