Slowing down as we age: aging of the cardiac pacemaker's neural control.
Slowing down as we age: aging of the cardiac pacemaker's neural control.
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DOI：
10.1007/s11357-021-00420-3
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发表时间：
2022-03
期刊：
影响因子：
5.6
通讯作者：
Moreno CM
中科院分区：
文献类型：
--
作者：
Choi S;Baudot M;Vivas O;Moreno CM
心脏起搏器点燃并协调整个心脏的收缩，不间断地贯穿我们的一生。心脏起搏器的频率由自主神经系统不断调节，以维持体内平衡。交感神经末梢和副交感神经末梢在起搏器细胞上充当加速器和刹车踏板，增加或减少起搏器细胞的放电速率以适应生理需求。尽管这种组织具有显著的可靠性，但起搏器也不能免于衰老的有害影响。哺乳动物在整个生命周期中都会经历心脏起搏器频率的自然和持续下降。为什么心脏起搏器的节律会随着年龄的增长而减慢，人们对此知之甚少。从出生到成年，起搏器的神经控制被重塑，有强有力的证据表明，与年龄相关的功能障碍导致起搏器的降速。这些证据包括起搏器组织结构的重塑，神经支配的改变，交感加速和副交感减速的改变，以及起搏器细胞对肾上腺素能和胆碱能调节的反应性的改变。在这篇综述中，我们回顾了在组织和细胞水平上对起搏器的神经控制的主要证据，以及衰老对形成这种神经控制的影响。
The cardiac pacemaker ignites and coordinates the contraction of the whole heart, uninterruptedly, throughout our entire life. Pacemaker rate is constantly tuned by the autonomous nervous system to maintain body homeostasis. Sympathetic and parasympathetic terminals act over the pacemaker cells as the accelerator and the brake pedals, increasing or reducing the firing rate of pacemaker cells to match physiological demands. Despite the remarkable reliability of this tissue, the pacemaker is not exempt from the detrimental effects of aging. Mammals experience a natural and continuous decrease in the pacemaker rate throughout the entire lifespan. Why the pacemaker rhythm slows with age is poorly understood. Neural control of the pacemaker is remodeled from birth to adulthood, with strong evidence of age-related dysfunction that leads to a downshift of the pacemaker. Such evidence includes remodeling of pacemaker tissue architecture, alterations in the innervation, changes in the sympathetic acceleration and the parasympathetic deceleration, and alterations in the responsiveness of pacemaker cells to adrenergic and cholinergic modulation. In this review, we revisit the main evidence on the neural control of the pacemaker at the tissue and cellular level and the effects of aging on shaping this neural control.
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影响因子：
64.8
作者：
Baker DJ;Childs BG;Durik M;Wijers ME;Sieben CJ;Zhong J;Saltness RA;Jeganathan KB;Verzosa GC;Pezeshki A;Khazaie K;Miller JD;van Deursen JM
通讯作者：
van Deursen JM
影响因子：
3.5
作者：
Antonio Moro-Garcia, Marco;Echeverria, Ainara;Alonso-Arias, Rebeca
通讯作者：
Alonso-Arias, Rebeca
影响因子：
20.1
作者：
BEAU, SL;HAND, DE;SAFFITZ, JE
通讯作者：
SAFFITZ, JE
影响因子：
3.3
作者：
Christou, Demetra D.;Seals, Douglas R.
通讯作者：
Seals, Douglas R.
影响因子：
--
作者：
BOLTER, CP;ATKINSON, KJ
通讯作者：
ATKINSON, KJ