Methodologic Considerations for Epigenomic Investigation of Preterm Birth in African American Women.
Methodologic Considerations for Epigenomic Investigation of Preterm Birth in African American Women.
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DOI：
10.1177/01939459211030339
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发表时间：
2022-01
影响因子：
1.8
通讯作者：
Anderson CM
中科院分区：
文献类型：
--
作者：
Nowak AL;Giurgescu C;Ford JL;Mackos A;Ohm J;Tan A;Pietrzak M;Anderson CM
表观遗传修饰是指在不改变基因序列的情况下改变基因表达的化学变化。这些修饰是潜在的可识别和可逆的，使表观基因组成为发现生物标志物的重要研究领域，以识别那些可能处于风险中的人，并提供治疗干预措施以防止不良健康结果。非裔美国人承受着不成比例的不良健康后果风险（例如，高血压、癌症）。事实上，非裔美国妇女经历早产（PTB; <37周妊娠）的比率是非西班牙裔白色妇女的两倍多。研究表明，环境影响可能在这一人群的PTB结局中发挥重要作用。然而，这些影响导致PTB的生物学途径知之甚少。本文介绍了研究方法和伦理考虑收集和分析生物样本的基础上，我们的研究检查PTB的压力途径在怀孕的非洲裔美国妇女的表观遗传调控。
Epigenetic modifications are chemical changes that can modify gene expression without changing the sequence of the gene. These modifications are potentially identifiable and reversible, making the epigenome an important area of research for discovering biomarkers to identify those who may be at risk and providing therapeutic interventions to prevent adverse health outcomes. African Americans bear a disproportionate risk of adverse health outcomes (e.g., hypertension, cancer). Indeed, African American women experience preterm birth (PTB; <37 completed weeks gestation) at more than twice the rate of non-Hispanic White women. Research suggests that environmental influences may play a significant role in PTB outcomes for this population. However, the biological pathways by which these influences contribute to PTB are poorly understood. This paper describes research methods and ethical considerations for the collection and analysis of biological samples based on our study examining the epigenetic regulation of stress pathways in PTB in pregnant African American women.
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