The significance of Stanniocalcin 2 in malignancies and mechanisms.
The significance of Stanniocalcin 2 in malignancies and mechanisms.
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DOI：
10.1080/21655979.2021.1977551
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发表时间：
2021-12
期刊：
影响因子：
4.9
通讯作者：
Wu Z
中科院分区：
文献类型：
--
作者：
Li S;Huang Q;Li D;Lv L;Li Y;Wu Z
人斯钙素 2 (STC2) 是鱼类斯钙素 (STC) 的直系同源物，广泛表达于多种器官和组织中。该基因位于染色体 5q33 或 5q35 上。 STC2 与葡萄糖稳态和磷代谢有关。据报道，它还与多种恶性肿瘤有关。 STC2被发现与乳腺癌和妇科癌症有关，表明在这些恶性肿瘤中具有激素特异性或依赖性活性。此外，据报道它还与胃肠道肿瘤（包括食道癌、胃癌、结直肠癌和肝癌）以及呼吸道癌症（包括喉癌和肺癌）有关。它还影响肾癌和前列腺癌。值得注意的是，作为一种分泌性磷蛋白，STC2 在血清中可检测到，并且在多种恶性肿瘤中具有良好的预测价值。本综述旨在提高对STC2在患者诊断和预后、肿瘤发生和进展中的作用以及所涉及机制的理解。
Human stanniocalcin 2 (STC2) is an ortholog of fish stanniocalcins (STCs) and is widely expressed in various organs and tissues. The gene is localized on chromosome 5q33 or 5q35. STC2 has been implicated in glucose homeostasis and phosphorus metabolism. It is also reported to be implicated in various malignancies. STC2 was found to be implicated in breast cancer and gynecologic cancers, suggesting hormone-specific or -dependent activities in these malignancies. Moreover, it was reported to be involved in gastrointestinal tumors, including esophageal, gastric, colorectal, and liver cancers, and respiratory cancers, including laryngeal and lung cancers. It also influenced renal carcinoma and prostate cancer. Notably, as a secreted phosphoprotein, STC2 was detectable in serum and possessed promising predictive value in several malignancies. This review aims to improve the understanding of the role of STC2 in patient diagnosis and prognosis, and tumor development and progression, as well as the mechanisms involved.
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DOI：
10.26355/eurrev_201910_19282
发表时间：
2019-01-01
影响因子：
3.3
作者：
Ke, J.;Zhang, B-H;Cai, Y-D
通讯作者：
Cai, Y-D
DOI：
10.1002/cjp2.106
发表时间：
2018-10
期刊：
The journal of pathology. Clinical research
影响因子：
--
作者：
Coulson-Gilmer C;Humphries MP;Sundara Rajan S;Droop A;Jackson S;Condon A;Cserni G;Jordan LB;Jones LJ;Kanthan R;Di Benedetto A;Mottolese M;Provenzano E;Kulka J;Shaaban AM;Hanby AM;Speirs V
通讯作者：
Speirs V
影响因子：
1.3
作者：
Ji, Zhi-Yong;Li, Hai-Feng;Zhang, Yan-Lin
通讯作者：
Zhang, Yan-Lin
影响因子：
3.3
作者：
He, Huocong;Qie, Shuo;Lin, Shaojun
通讯作者：
Lin, Shaojun
影响因子：
3.4
作者：
Hashemzadeh, Shahryar;Arabzadeh, Amir Ahmad;Sakhinia, Ebrahim
通讯作者：
Sakhinia, Ebrahim