Effects of dexmedetomidine on the function of distal organs and oxidative stress after lower limb ischaemia-reperfusion in elderly patients undergoing unilateral knee arthroplasty.
Effects of dexmedetomidine on the function of distal organs and oxidative stress after lower limb ischaemia-reperfusion in elderly patients undergoing unilateral knee arthroplasty.
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右美托咪定对老年单侧膝关节置换术患者下肢缺血再灌注后远端器官功能及氧化应激的影响
DOI：
10.1111/bcp.14830
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发表时间：
2021-11
影响因子：
3.4
通讯作者：
Gu J
中科院分区：
文献类型：
--
作者：
Lu S;Chen X;Chen Q;Cahilog Z;Hu L;Chen Y;Cao J;Ning J;Yi B;Lu K;Gu J
本研究旨在评估右美托咪定对单侧全膝关节置换术中医源性下肢缺血再灌注（IR）老年患者器官功能、炎症反应和氧化应激的影响。单侧全膝关节置换术后，54 名老年患者被随机分配接受术中静脉注射右美托咪定 (n = 27) 或等量的 0.9% 生理盐水 (n = 27)。下肢止血带松开前 5 分钟采集血样（基线）；以及止血带释放后 1、6 和 24 小时。记录并分析了心脏、肺、肝和肾功能、氧化应激、炎症反应以及副交感神经和交感神经活动的替代标志物。止血带引起的下肢IR损伤后患者的血液黄嘌呤氧化酶、肌酸激酶、乳酸和呼吸指数水平升高。右美托咪定给药可降低 1、6 和 24 小时的呼吸指数（P = .014、P = .01 和 P = .043）和去甲肾上腺素水平（P < .001）；与对照组相比，在止血带释放后 6 小时和 24 小时，黄嘌呤氧化酶水平降低（P = .049，P < .001）。其他测量值，包括肌酸激酶同工酶、乳酸脱氢酶、肌酐、尿素氮、谷氨酸-草乙酸转氨酶、谷氨酸-丙酮酸转氨酶、丙二醛、白细胞介素-1、白细胞介素-6和肿瘤坏死因子-α，在两组之间没有统计学上的显着差异。老年患者术中给予右美托咪定可抑制老年患者医源性下肢IR损伤后呼吸功能的恶化并抑制氧化应激反应。
This study aims to evaluate the effects of dexmedetomidine on organ function, inflammation response, and oxidative stress in elderly patients following iatrogenic lower limb ischaemia–reperfusion (IR) during unilateral total knee arthroplasty. Following unilateral total knee arthroplasty, 54 elderly patients were randomized to receive either intraoperative intravenous injection of dexmedetomidine (n = 27) or equivalent volume of 0.9% saline (n = 27). Blood samples were harvested at 5 minutes before lower limb tourniquet release (baseline); and 1, 6 and 24 hours after tourniquet release. Surrogate markers of cardiac, pulmonary, hepatic and renal function, oxidative stress, inflammatory response, along with parasympathetic and sympathetic activity were recorded and analysed. The levels of blood xanthine oxidase, creatine kinase, lactic acid and respiratory index increased in patients following tourniquet‐induced lower limb IR injury. Dexmedetomidine administration decreased the respiratory index (P = .014, P = .01, and P = .043) and the norepinephrine level (P < .001) at 1, 6 and 24 hours; and decreased the xanthine oxidase level (P = .049, P < .001) at 6 and 24 hours after tourniquet release compared with the Control group. Other measurements, including creatine kinase isoenzyme, lactate dehydrogenase, creatinine, urea nitrogen, glutamic–oxalacetic transaminase, glutamic–pyruvic transaminase, malondialdehyde, interleukin‐1, interleukin‐6 and tumour necrosis factor‐α, were not statistically significantly different between the 2 groups. Intraoperative dexmedetomidine administration in elderly patients dampens the deterioration in respiratory function and suppresses the oxidative stress response in elderly patients following iatrogenic lower limb IR injury.
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影响因子：
2.6
作者：
Amani, Mohammad;Jeddi, Sajad;Zaman, Jalal
通讯作者：
Zaman, Jalal
DOI：
10.1016/b978-0-12-394309-5.00006-7
发表时间：
2012
影响因子：
--
作者：
Kalogeris, Theodore;Baines, Christopher P.;Krenz, Maike;Korthuis, Ronald J.
通讯作者：
Korthuis, Ronald J.
大鼠无创延迟肢体缺血预处理可增加严重缺血再灌注损伤期间脑组织的抗氧化活性
影响因子：
2.2
作者：
Yuan, Heng-Jie;Zhu, Xue-Hui;Lou, Jian-Shi
通讯作者：
Lou, Jian-Shi
影响因子：
9.8
作者：
Si, Y.;Bao, H.;Geng, Y.
通讯作者：
Geng, Y.
影响因子：
3.5
作者：
Li, Yong-Hua;Wang, Yong-Qiang;Tian, Mou-Li
通讯作者：
Tian, Mou-Li