A likelihood-based method for real-time estimation of the serial interval and reproductive number of an epidemic.

A likelihood-based method for real-time estimation of the serial interval and reproductive number of an epidemic.
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DOI:
10.1002/sim.3136
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发表时间:
2008-07-20
影响因子:
2
通讯作者:
Pagano, M.
Pagano, M.
中科院分区:
医学3区
文献类型:
--
作者:
White, L. Forsberg;Pagano, M.

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我们提出了一种利用现成的监测数据同时估计传染病流行的基本再生数 R0 和序列间隔的方法。可以实时获得这些估计值,以便为应对疫情采取适当的公共卫生应对措施提供信息。我们展示了这种方法在最简单的情况下如何与分支过程相关,并描述了两者之间的相似之处,使我们能够进行相似之处,从而使我们能够理解估计器的一些理论属性。我们提供的仿真结果说明了该方法实时估计 R0 和串行间隔的有效性。最后,我们利用来自三个传染病爆发的数据来实施我们提出的方法。
We present a method for the simultaneous estimation of the basic reproductive number, R0, and the serial interval for infectious disease epidemics, using readily available surveillance data. These estimates can be obtained in real time to inform an appropriate public health response to the outbreak. We show how this methodology, in its most simple case, is related to a branching process and describe similarities between the two that allow us to draw parallels which enable us to understand some of the theoretical properties of our estimators. We provide simulation results that illustrate the efficacy of the method for estimating R0 and the serial interval in real time. Finally, we implement our proposed method with data from three infectious disease outbreaks.
1918年大流行性流感的传播性。
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