Recovery of human immunodeficiency virus type 1 from semen: minimal impact of stage of infection and current antiviral chemotherapy.

Recovery of human immunodeficiency virus type 1 from semen: minimal impact of stage of infection and current antiviral chemotherapy.
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从精液中回收 1 型人类免疫缺陷病毒:感染阶段和当前抗病毒化疗的影响最小。

DOI:
10.1093/infdis/163.2.386
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发表时间:
1991
期刊:
The Journal of infectious diseases
影响因子:
--
通讯作者:
Corey,L
Corey,L
中科院分区:
--
文献类型:
--
作者:
Krieger,JN;Coombs,RW;Collier,AC;Ross,SO;Chaloupka,K;Cummings,DK;Murphy,VL;Corey,L

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由于精液暴露对人类免疫缺陷病毒1型(HIV)的性传播很重要,因此研究了感染阶段和抗病毒化疗与从精液中分离HIV的关系。虽然HIV是从所有血清反应阳性者的外周血单个核细胞中分离出来的,但34名男性中只有11名(32%)从精液中分离出来,其中包括6名随时间顺序研究的男性中的3名。从14名无症状患者(疾病控制中心[CDC] II级或III级)的19份精液标本中分离出6份(32%)HIV,从20名有症状患者(CDC IV级)的36份精液标本中分离出10份(28%)HIV。从精液中分离HIV与CD4+或CD8+T淋巴细胞计数或齐多夫定治疗无关。血清阳性的男性在感染过程的早期可能会通过精液排出HIV,而齐多夫定治疗似乎对HIV的恢复没有影响,因此,对HIV的性传播可能性没有影响。
Because exposure to semen is important for the sexual transmission of human immunodeficiency virus type 1 (HIV), the relationship of stage of infection and antiviral chemotherapy to isolation ofHIV from semen was investigated. Whereas HIV was isolated from peripheral blood mononuclear cells of all seropositive persons tested, it was isolated from semen in only 11 (32%) of 34 men, including 3 of 6 who were studied sequentially over time. HIV was isolated from 6 (32%) of 19 semen specimens from 14 asymptomatic persons (Centers for Disease Control [CDC] class II or III) and from 10 (28%) of 36 semen specimens from 20 symptomatic patients (CDC class IV). Isolation of HIV from semen did not correlate with CD4+or CD8+T lymphocytes counts or zidovudine therapy. Seropositive men may shed HIV in semen early in the course ofinfection, and zidovudine therapy seems to have no effect on the recovery of HIV and, thus, on the potential for sexual transmission of HIV.
艾滋病的传播:受感染细胞的情况。
DOI: 10.1001/jama.1988.03720200059035
发表时间: 1988
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通过放射免疫测定同时测定艾滋病或艾滋病相关综合症患者精液和血清中的齐多夫定水平。
DOI: --
发表时间: 1988
期刊: JAMA
影响因子: --
作者:
Henry,K;Chinnock,BJ;Quinn,RP;Fletcher,CV;deMiranda,P;BalfourJr,HH
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