Culture-gene coevolution of individualism-collectivism and the serotonin transporter gene.
Culture-gene coevolution of individualism-collectivism and the serotonin transporter gene.
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DOI：
10.1098/rspb.2009.1650
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发表时间：
2010-02-22
期刊：
影响因子：
--
通讯作者：
Blizinsky KD
中科院分区：
文献类型：
--
作者：
Chiao JY;Blizinsky KD
文化-基因共同进化理论认为，文化价值观已经进化，具有适应性，并影响着基因选择所处的社会和自然环境。在这里，我们研究了个人主义-集体主义的文化价值观和5-羟色胺转运体功能多态(5-HTTLPR)的等位基因频率之间的关联，以及这种文化-基因关联在解释病原体和情感障碍流行率的全球变异性中可能发挥的作用。我们发现有证据表明，集体主义文化明显更有可能包括29个国家的携带5-HTTLPR短等位基因(S)的个人。结果进一步表明，由于S等位基因的遗传选择，历史病原体流行预测了个人主义-集体主义的文化变异性。此外，文化价值观和S等位基因携带者的频率对焦虑和情绪障碍的全球流行具有负面预测作用。最后，中介分析进一步表明，S等位基因携带者频率的增加预示着焦虑和情绪障碍患病率的降低，这是由于集体主义文化价值观的提高。综上所述，我们的发现表明，5-HTTLPR的等位基因频率和个人主义-集体主义的文化价值观之间存在文化-基因协同进化，并支持文化价值观缓冲遗传易感人群免受情感障碍患病率增加的影响。讨论了目前的发现对于理解人类大脑和行为的文化-基因共同进化的意义，以及这种共同进化过程如何有助于病原体流行率和情感障碍(如焦虑和抑郁)的流行病学的全球差异。
Culture–gene coevolutionary theory posits that cultural values have evolved, are adaptive and influence the social and physical environments under which genetic selection operates. Here, we examined the association between cultural values of individualism–collectivism and allelic frequency of the serotonin transporter functional polymorphism (5-HTTLPR) as well as the role this culture–gene association may play in explaining global variability in prevalence of pathogens and affective disorders. We found evidence that collectivistic cultures were significantly more likely to comprise individuals carrying the short (S) allele of the 5-HTTLPR across 29 nations. Results further show that historical pathogen prevalence predicts cultural variability in individualism–collectivism owing to genetic selection of the S allele. Additionally, cultural values and frequency of S allele carriers negatively predict global prevalence of anxiety and mood disorder. Finally, mediation analyses further indicate that increased frequency of S allele carriers predicted decreased anxiety and mood disorder prevalence owing to increased collectivistic cultural values. Taken together, our findings suggest culture–gene coevolution between allelic frequency of 5-HTTLPR and cultural values of individualism–collectivism and support the notion that cultural values buffer genetically susceptible populations from increased prevalence of affective disorders. Implications of the current findings for understanding culture–gene coevolution of human brain and behaviour as well as how this coevolutionary process may contribute to global variation in pathogen prevalence and epidemiology of affective disorders, such as anxiety and depression, are discussed.
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影响因子：
2.9
作者：
Dressler, William W.;Balieiro, Mauro C.;Dos Santos, Jose Ernesto
通讯作者：
Dos Santos, Jose Ernesto
DOI：
10.1098/rspb.2008.1788
发表时间：
2009-05-22
期刊：
Proceedings. Biological sciences
影响因子：
--
作者：
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通讯作者：
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作者：
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通讯作者：
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影响因子：
3.2
作者：
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通讯作者：
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影响因子：
7.6
作者：
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通讯作者：
NOWICKI, GP