Hepatitis B virus infection in a cohort of HIV infected blood donors and AIDS patients in Sichuan, China.
Hepatitis B virus infection in a cohort of HIV infected blood donors and AIDS patients in Sichuan, China.
复制标题
中国四川省一群感染艾滋病毒的献血者和艾滋病患者的乙型肝炎病毒感染情况
DOI：
10.1186/1479-5876-12-164
复制
发表时间：
2014-06-12
影响因子：
7.4
通讯作者：
Liu Z
中科院分区：
文献类型：
--
作者：
Liu Y;Zeng P;Wang J;Liu G;Xu M;Ke L;He M;Liu Z
研究背景HBV和HIV的共同感染是常见的，因为它们的传播途径相似。由于血液传播是HBV和HIV的重要传播途径，因此评估HIV感染献血者中HBV的流行情况对于输血安全可能很重要。此外，由于HBV在HIV感染者和献血员中的流行病学特征可能存在差异，因此了解HBV在HIV感染者中的流行病学特征对治疗和预防HBV感染具有重要意义。方法收集614例HIV阳性献血员和患者血清，进行HBsAg和HBV DNA检测。对筛选出的HBsAg阳性或HBV DNA阳性的标本进行抗-HBs、HBeAg、抗-HBe和抗-HBc等HBV血清学标志物检测。结果614例HIV感染者中有79例（12.9%）合并HBV感染，其中献血员42例（10.1%），AIDS患者37例（18.8%）。HBsAg阳性者中HBeAg阴性者占80.0%，其中HBVDNA阴性者占10.0%，HBVDNA <2000 IU/ml者占38.3%。供者的平均HBV DNA水平低于患者。在HBV DNA阳性人群中，HBV基因型B型占48.1%，A型占22.8%，C型占8.86%。4例HBsAg-/HBV DNA +受试者中有2例出现与HBsAg检测失败相关的突变。因此，我们建议在中国对新诊断的HIV/AIDS患者进行HBV常规检测。一些HIV和HBV合并感染的患者如果仅使用HBV的常规血清学标志物仍不能确诊，因此检测HBV DNA对于HIV感染者很重要。HBeAg阴性患者的HBV DNA水平相对较低，因此该血清学标志物可能有助于在HBV DNA不可用的情况下优先考虑患者对HBV治疗的需求。
BackgroundCo-infections of HBV and HIV are frequent due to similar routes of transmission. In that transmission through blood is an important route for both HBV and HIV, evaluation of the prevalence of HBV in HIV infected blood donors may be important for transfusion safety. In addition, because the epidemiological characteristics of HBV in HIV infected patients and blood donors may differ from each other, understanding of it could be significant for therapy and prevention of HBV in HIV infected adults. However, data reported on these in Chinese people remains limited.Methods614 HIV confirmed positive samples were collected from blood donors and patients and were screened for HBsAg and HBV DNA. The samples screened reactive for HBsAg or positive for HBV DNA were tested for the other serological markers of HBV including anti-HBs, HBeAg, anti-HBe and anti-HBc. For the samples tested positive for HBV DNA, the S region of HBV was amplified by nested PCR and the HBV genotypes were determined.ResultsHBV coinfections were found in 12.9% (79/614) HIV infected individuals including 42/417(10.1%) blood donors and 37/197 (18.8%) AIDS patients. In the HBsAg positive individuals, 80.0% were HBeAg negative in which 10.0% were HBV DNA negative and 38.3% with HBV DNA lower than 2000 IU/ml. The average HBV DNA levels were lower in donors than in patients. In the HBV DNA positive populations, HBV genotypes B, A and C accounted for 48.1%, 22.8% and 8.86% respectively. Mutations related to the failure of HBsAg detection were found in 2 of the 4 HBsAg-/HBV DNA + subjects.ConclusionsHigh prevalence of HBV in HIV infected individuals was found in this study. Hence, we recommend routine testing of HBV for patients newly diagnosed with HIV/AIDS in China. Some HIV-HBV co-infected patients remain undiagnosed if only conventional serological markers for HBV are used and it’s important to detect HBV DNA for HIV infected patients. HBV DNA levels were relatively low in HBeAg negative patients, thus this serologic marker may be useful in prioritizing patients on their need for HBV treatment in settings in which HBV DNA is not available.
登录
查看更多内容
影响因子：
3.7
作者：
Gupta S;Singh S
通讯作者：
Singh S
影响因子：
1.4
作者：
Zhao, Y. S.;Su, S. L.;Fu, J. H.
通讯作者：
Fu, J. H.
影响因子：
25.7
作者：
GRUMAYER, ER;PANZER, S;GADNER, H
通讯作者：
GADNER, H
影响因子：
3.8
作者：
WAITE, J;GILSON, RJC;TEDDER, RS
通讯作者：
TEDDER, RS
影响因子：
2.7
作者：
Liu, Yu;Wang, Jingxing;Huang, Yi;Yang, Tonghan;Guo, Xiaoming;Li, Julin;Wen, Guoxin;Yun, Zhongqiao;Zeng, Peibin;He, Miao;Xu, Min;Liu, Gui;Ke, Ling;Wright, David;Liu, Jing;Nelson, Kenrad;Shan, Hua
通讯作者：
Shan, Hua