Mitochondrial Antioxidants and the Maintenance of Cellular Hydrogen Peroxide Levels.
Mitochondrial Antioxidants and the Maintenance of Cellular Hydrogen Peroxide Levels.
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DOI：
10.1155/2018/7857251
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发表时间：
2018
影响因子：
--
通讯作者：
Mailloux RJ
中科院分区：
文献类型：
--
作者：
Mailloux RJ
40多年来，线粒体活性氧（ROS）的产生和平衡已经在氧化应激和组织损伤的背景下进行了研究。然而，过去十年的研究表明，线粒体与活性氧的关系更为复杂。超氧化物（O2•−）和过氧化氢（H2O2）是线粒体形成的近端活性氧，后者作为次级信使，协调氧化代谢与细胞生理变化。与任何其他次生信使一样，H2O2水平需要通过其产生和降解来调节，线粒体富含抗氧化防御，以降解由营养氧化和呼吸形成的ROS。最近的研究还表明，这些抗氧化系统也具有清除线粒体外形成的H2O2的能力。这些观察结果导致了线粒体作为缓冲细胞H2O2水平的“ROS稳定装置”的假设的发展。在这里，我提供了线粒体ROS稳态的最新观点，并讨论了哺乳动物细胞中线粒体的“ROS稳定”功能。接下来，我们将假定性地讨论线粒体和质子动力在降解胞质酶发出的细胞H2O2信号中的潜在功能。
For over 40 years, mitochondrial reactive oxygen species (ROS) production and balance has been studied in the context of oxidative distress and tissue damage. However, research over the past decade has demonstrated that the mitochondria have a more complicated relationship with ROS. Superoxide (O2•−) and hydrogen peroxide (H2O2) are the proximal ROS formed by the mitochondria, and the latter molecule is used as a secondary messenger to coordinate oxidative metabolism with changes in cell physiology. Like any other secondary messenger, H2O2 levels need to be regulated through its production and degradation and the mitochondria are enriched with the antioxidant defenses required to degrade ROS formed by nutrient oxidation and respiration. Recent work has also demonstrated that these antioxidant systems also carry the capacity to clear H2O2 formed outside of mitochondria. These observations led to the development of the postulate that the mitochondria serve as “ROS stabilizing devices” that buffer cellular H2O2 levels. Here, I provide an updated view on mitochondrial ROS homeostasis and discuss the “ROS stabilizing” function of the mitochondria in mammalian cells. This will be followed by a hypothetical discussion on the potential function of the mitochondria and proton motive force in degrading cellular H2O2 signals emanating from cytosolic enzymes.
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影响因子：
7.4
作者：
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影响因子：
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作者：
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作者：
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影响因子：
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作者：
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DOI：
10.1016/j.bbrc.2018.02.208
发表时间：
2018-03-25
影响因子：
3.1
作者：
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通讯作者：
Mailloux, Ryan J.