Integration of cellular bioenergetics with mitochondrial quality control and autophagy.
Integration of cellular bioenergetics with mitochondrial quality control and autophagy.
复制标题
DOI：
10.1515/hsz-2012-0198
复制
发表时间：
2012-12
影响因子：
3.7
通讯作者：
Darley-Usmar VM
中科院分区：
文献类型：
--
作者：
Hill BG;Benavides GA;Lancaster JR Jr;Ballinger S;Dell'Italia L;Jianhua Z;Darley-Usmar VM
生物能量功能障碍正在成为建立理解心血管疾病、糖尿病、癌症和神经变性的病理生理学框架的基石。细胞生物能量学的最新进展表明，许多细胞保持着相当大的生物能量储备能力，这是一个“健康”线粒体群体的前瞻性指标。细胞的生物能量学可能受能量需求和底物可用性的调节。此外，线粒体群体的整体质量以及细胞和组织中线粒体的相对丰度也影响整体生物能量能力和对压力的抵抗力。由于线粒体易受活性氧/氮和脂质物质介导的损伤，因此通过质量控制机制维持线粒体的“健康”群体对于病理应激条件下的细胞存活似乎是必不可少的。越来越多的证据表明，线粒体自噬对于防止初始氧化损伤的放大特别重要，否则会进一步损害呼吸链或促进线粒体DNA（mtDNA）突变。线粒体自噬的调控过程依赖于几个因素，包括mtDNA的完整性，电子传递链的活性，以及自噬机制的相互作用和调节。在线粒体质量控制和遗传学的背景下，细胞生物能量学的整合和解释是本次审查的主题。
Bioenergetic dysfunction is emerging as a cornerstone for establishing a framework for understanding the pathophysiology of cardiovascular disease, diabetes, cancer and neurodegeneration. Recent advances in cellular bioenergetics have shown that many cells maintain a substantial bioenergetic reserve capacity, which is a prospective index of “healthy” mitochondrial populations. The bioenergetics of the cell are likely regulated by energy requirements and substrate availability. Additionally, the overall quality of the mitochondrial population and the relative abundance of mitochondria in cells and tissues also impinge on overall bioenergetic capacity and resistance to stress. Because mitochondria are susceptible to damage mediated by reactive oxygen/nitrogen and lipid species, maintaining a “healthy” population of mitochondria through quality control mechanisms appears to be essential for cell survival under conditions of pathological stress. Accumulating evidence suggest that mitophagy is particularly important for preventing amplification of initial oxidative insults, which otherwise would further impair the respiratory chain or promote mutations in mitochondrial DNA (mtDNA). The processes underlying the regulation of mitophagy depend on several factors including the integrity of mtDNA, electron transport chain activity, and the interaction and regulation of the autophagic machinery. The integration and interpretation of cellular bioenergetics in the context of mitochondrial quality control and genetics is the theme of this review.
登录
查看更多内容
影响因子：
7.8
作者：
ASHFORD, T P;PORTER, K R
通讯作者：
PORTER, K R
影响因子：
4.1
作者：
Amo, Taku;Brand, Martin D.
通讯作者：
Brand, Martin D.
影响因子：
4.2
作者：
Brunengraber, Henri;Roe, Charles R.
通讯作者：
Roe, Charles R.
影响因子：
4.1
作者：
Affourtit, Charles;Brand, Martin D.
通讯作者：
Brand, Martin D.
影响因子：
7.7
作者：
Bhopal, Raj S.;Rafnsson, Snorri B.
通讯作者：
Rafnsson, Snorri B.