Disposable copper-based electrochemical sensor for anodic stripping voltammetry.
Disposable copper-based electrochemical sensor for anodic stripping voltammetry.
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DOI：
10.1021/ac500277j
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发表时间：
2014-05-20
影响因子：
7.4
通讯作者：
Papautsky, Ian
中科院分区：
文献类型：
--
作者：
Pei, Xing;Kang, Wenjing;Yue, Wei;Bange, Adam;Heineman, William R.;Papautsky, Ian
在这项工作中，我们报告了第一个用于电化学测量的铜基护理点传感器，通过血清中的锌测定来证明。重金属需要仔细监测，但目前的方法对于即时护理系统来说过于复杂。电化学为微尺度金属检测提供了一种简单的方法，但传统的碳、金 (Au) 或铂 (Pt) 电极的微制造困难或昂贵，阻碍了广泛使用。我们的传感器采用新型低成本电极材料铜，该材料制造简单且与微加工和 PCB 加工兼容，同时保持电化学检测方面的竞争性能。使用我们的新型铜基传感器对锌进行阳极溶出伏安法，在醋酸盐缓冲液中显示出 140 nM (9.0 ppb) 的检测限（计算值）和大于 1 μA/μM 的灵敏度。该传感器还能够测定牛血清提取物中的锌，并通过独立的传感器测量验证结果。这些结果证明了这种芯片实验室电化学传感器在临床应用中的优势，包括样品量小（μL 级）、成本降低、响应时间短以及低浓度分析物下的高精度。
In this work, we report the first copper-based point-of-care sensor for electrochemical measurements demonstrated by zinc determination in blood serum. Heavy metals require careful monitoring, yet current methods are too complex for a point-of-care system. Electrochemistry offers a simple approach to metal detection on the microscale, but traditional carbon, gold (Au), or platinum (Pt) electrodes are difficult or expensive to microfabricate, preventing widespread use. Our sensor features a new low-cost electrode material, copper, which offers simple fabrication and compatibility with microfabrication and PCB processing, while maintaining competitive performance in electrochemical detection. Anodic stripping voltammetry of zinc using our new copper-based sensors exhibited a 140 nM (9.0 ppb) limit of detection (calculated) and sensitivity greater than 1 μA/μM in the acetate buffer. The sensor was also able to determine zinc in a bovine serum extract, and the results were verified with independent sensor measurements. These results demonstrate the advantageous qualities of this lab-on-a-chip electrochemical sensor for clinical applications, which include a small sample volume (μL scale), reduced cost, short response time, and high accuracy at low concentrations of analyte.
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影响因子：
6.2
作者：
Matsumoto, T;Ohashi, A;Ito, N
通讯作者：
Ito, N
影响因子：
3
作者：
Jothimuthu, Preetha;Wilson, Robert A.;Herren, Josi;Pei, Xing;Kang, Wenjing;Daniels, Rodney;Wong, Hector;Beyette, Fred;Heineman, William R.;Papautsky, Ian
通讯作者：
Papautsky, Ian
影响因子：
6.1
作者：
Guo, ZY;Feng, F;Jaffrezic-Renault, N
通讯作者：
Jaffrezic-Renault, N
影响因子：
2
作者：
Kumar, MP;Mouli, PC;Mohan, SV
通讯作者：
Mohan, SV
影响因子：
4.2
作者：
Hambidge, K. Michael;Krebs, Nancy F.
通讯作者：
Krebs, Nancy F.